C-type lectin domain family 2 member D

UniProt data

UniProt name: CLC2D_HUMAN (Q9UHP7)

Gene name: CLEC2D; Synonyms=CLAX, LLT1, OCIL

Organism: Homo sapiens (Human).

Function: Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis. Inhibits osteoclast formation. Inhibits bone resorption. Modulates the release of interferon- gamma. Binds high molecular weight sulfated glycosaminoglycans. {ECO:0000269|PubMed:14753741, ECO:0000269|PubMed:15104121, ECO:0000269|PubMed:16339513}.

Subcellular location: Isoform 4: Endoplasmic reticulum.

Transmembrane domains:

  1. 39-59, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 191 AA

10 20 30 40 50 60 MHDSNNVEKD ITPSELPANP GCLHSKEHSI KATLIWRLFF LIMFLTIIVC GMVAALSAIR 70 80 90 100 110 120 ANCHQEPSVC LQAACPESWI GFQRKCFYFS DDTKNWTSSQ RFCDSQDADL AQVESFQELN 130 140 150 160 170 180 FLLRYKGPSD HWIGLSREQG QPWKWINGTE WTRQFPILGA GECAYLNDKG ASSARHYTER 190 KWICSKSDIH V

CATM prediction

The sequence of CLC2D_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      40        50        60 
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 WRLFFLIMFLTIIVCGMVAALSAIRAN 7.0 -55.0° 0.9 49.8 -19.8
Model 2 WRLFFLIMFLTIIVCGMVAALSAIRAN 7.2 -37.1° 2.3 36.0 -0.8

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 51, GLY, HA1 A, 48, ILE, O 3.10Å
B, 52, MET, HA A, 51, GLY, O 3.23Å
A, 51, GLY, HA1 B, 48, ILE, O 3.10Å
A, 52, MET, HA B, 51, GLY, O 3.23Å