Contactin-associated protein-like 2

UniProt data

UniProt name: CNTP2_HUMAN (Q9UHC6)

Gene name: CNTNAP2; Synonyms=CASPR2 {ECO:0000303|PubMed:10624965}, KIAA0868

Organism: Homo sapiens (Human).

Function: May play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the juxtaparanodal region of the axo-glial junction (By similarity). {ECO:0000250}.

Subcellular location: Membrane {ECO:0000250|UniProtKB:Q9CPW0}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, axon {ECO:0000250|UniProtKB:Q9CPW0}.

Transmembrane domains:

  1. 1263-1283, 21 AA, Helical. {ECO:0000255}.

Sequence: 1331 AA

10 20 30 40 50 60 MQAAPRAGCG AALLLWIVSS CLCRAWTAPS TSQKCDEPLV SGLPHVAFSS SSSISGSYSP 70 80 90 100 110 120 GYAKINKRGG AGGWSPSDSD HYQWLQVDFG NRKQISAIAT QGRYSSSDWV TQYRMLYSDT 130 140 150 160 170 180 GRNWKPYHQD GNIWAFPGNI NSDGVVRHEL QHPIIARYVR IVPLDWNGEG RIGLRIEVYG 190 200 210 220 230 240 CSYWADVINF DGHVVLPYRF RNKKMKTLKD VIALNFKTSE SEGVILHGEG QQGDYITLEL 250 260 270 280 290 300 KKAKLVLSLN LGSNQLGPIY GHTSVMTGSL LDDHHWHSVV IERQGRSINL TLDRSMQHFR 310 320 330 340 350 360 TNGEFDYLDL DYEITFGGIP FSGKPSSSSR KNFKGCMESI NYNGVNITDL ARRKKLEPSN 370 380 390 400 410 420 VGNLSFSCVE PYTVPVFFNA TSYLEVPGRL NQDLFSVSFQ FRTWNPNGLL VFSHFADNLG 430 440 450 460 470 480 NVEIDLTESK VGVHINITQT KMSQIDISSG SGLNDGQWHE VRFLAKENFA ILTIDGDEAS 490 500 510 520 530 540 AVRTNSPLQV KTGEKYFFGG FLNQMNNSSH SVLQPSFQGC MQLIQVDDQL VNLYEVAQRK 550 560 570 580 590 600 PGSFANVSID MCAIIDRCVP NHCEHGGKCS QTWDSFKCTC DETGYSGATC HNSIYEPSCE 610 620 630 640 650 660 AYKHLGQTSN YYWIDPDGSG PLGPLKVYCN MTEDKVWTIV SHDLQMQTPV VGYNPEKYSV 670 680 690 700 710 720 TQLVYSASMD QISAITDSAE YCEQYVSYFC KMSRLLNTPD GSPYTWWVGK ANEKHYYWGG 730 740 750 760 770 780 SGPGIQKCAC GIERNCTDPK YYCNCDADYK QWRKDAGFLS YKDHLPVSQV VVGDTDRQGS 790 800 810 820 830 840 EAKLSVGPLR CQGDRNYWNA ASFPNPSSYL HFSTFQGETS ADISFYFKTL TPWGVFLENM 850 860 870 880 890 900 GKEDFIKLEL KSATEVSFSF DVGNGPVEIV VRSPTPLNDD QWHRVTAERN VKQASLQVDR 910 920 930 940 950 960 LPQQIRKAPT EGHTRLELYS QLFVGGAGGQ QGFLGCIRSL RMNGVTLDLE ERAKVTSGFI 970 980 990 1000 1010 1020 SGCSGHCTSY GTNCENGGKC LERYHGYSCD CSNTAYDGTF CNKDVGAFFE EGMWLRYNFQ 1030 1040 1050 1060 1070 1080 APATNARDSS SRVDNAPDQQ NSHPDLAQEE IRFSFSTTKA PCILLYISSF TTDFLAVLVK 1090 1100 1110 1120 1130 1140 PTGSLQIRYN LGGTREPYNI DVDHRNMANG QPHSVNITRH EKTIFLKLDH YPSVSYHLPS 1150 1160 1170 1180 1190 1200 SSDTLFNSPK SLFLGKVIET GKIDQEIHKY NTPGFTGCLS RVQFNQIAPL KAALRQTNAS 1210 1220 1230 1240 1250 1260 AHVHIQGELV ESNCGASPLT LSPMSSATDP WHLDHLDSAS ADFPYNPGQG QAIRNGVNRN 1270 1280 1290 1300 1310 1320 SAIIGGVIAV VIFTILCTLV FLIRYMFRHK GTYHTNEAKG AESAESADAA IMNNDPNFTE 1330 TIDESKKEWL I

CATM prediction

The sequence of CNTP2_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  1260      1270      1280   
|    +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 NSAIIGGVIAVVIFTILCTLVFLIRYM 6.6 -47.0° 2.2 45.0 -26.7
Model 2 NSAIIGGVIAVVIFTILCTLVFLIRYM 7.0 -52.0° 5.2 40.0 -6.4

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 1266, GLY, HA2 A, 1265, GLY, O 3.12Å
A, 1266, GLY, HA2 B, 1265, GLY, O 3.12Å