SUN domain-containing protein 2

UniProt data

UniProt name: SUN2_HUMAN (Q9UH99)

Gene name: SUN2; Synonyms=FRIGG, KIAA0668, RAB5IP, UNC84B

Organism: Homo sapiens (Human).

Function: Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5. {ECO:0000269|PubMed:18396275}.

Subcellular location: Nucleus inner membrane {ECO:0000269|PubMed:15082709}; Single-pass type II membrane protein {ECO:0000269|PubMed:15082709}. Nucleus envelope {ECO:0000269|PubMed:15082709, ECO:0000269|PubMed:17132086, ECO:0000269|PubMed:17724119}. Endosome membrane {ECO:0000269|PubMed:10818110}; Single-pass type II membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 213-233, 21 AA, Helical.

Sequence: 717 AA

10 20 30 40 50 60 MSRRSQRLTR YSQGDDDGSS SSGGSSVAGS QSTLFKDSPL RTLKRKSSNM KRLSPAPQLG 70 80 90 100 110 120 PSSDAHTSYY SESLVHESWF PPRSSLEELH GDANWGEDLR VRRRRGTGGS ESSRASGLVG 130 140 150 160 170 180 RKATEDFLGS SSGYSSEDDY VGYSDVDQQS SSSRLRSAVS RAGSLLWMVA TSPGRLFRLL 190 200 210 220 230 240 YWWAGTTWYR LTTAASLLDV FVLTRRFSSL KTFLWFLLPL LLLTCLTYGA WYFYPYGLQT 250 260 270 280 290 300 FHPALVSWWA AKDSRRPDEG WEARDSSPHF QAEQRVMSRV HSLERRLEAL AAEFSSNWQK 310 320 330 340 350 360 EAMRLERLEL RQGAPGQGGG GGLSHEDTLA LLEGLVSRRE AALKEDFRRE TAARIQEELS 370 380 390 400 410 420 ALRAEHQQDS EDLFKKIVRA SQESEARIQQ LKSEWQSMTQ ESFQESSVKE LRRLEDQLAG 430 440 450 460 470 480 LQQELAALAL KQSSVAEEVG LLPQQIQAVR DDVESQFPAW ISQFLARGGG GRVGLLQREE 490 500 510 520 530 540 MQAQLRELES KILTHVAEMQ GKSAREAAAS LSLTLQKEGV IGVTEEQVHH IVKQALQRYS 550 560 570 580 590 600 EDRIGLADYA LESGGASVIS TRCSETYETK TALLSLFGIP LWYHSQSPRV ILQPDVHPGN 610 620 630 640 650 660 CWAFQGPQGF AVVRLSARIR PTAVTLEHVP KALSPNSTIS SAPKDFAIFG FDEDLQQEGT 670 680 690 700 710 LLGKFTYDQD GEPIQTFHFQ APTMATYQVV ELRILTNWGH PEYTCIYRFR VHGEPAH

CATM prediction

The sequence of SUN2_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  210       220       230    
|    +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 LKTFLWFLLALLLLTCLTYGAWYFYAY 7.0 -54.7° 1.5 45.0 -9.0
Prolines* LKTFLWFLLPLLLLTCLTYGAWYFYPY          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 226, LEU, HA A, 225, CYS, O 3.45Å
B, 229, GLY, HA1 A, 226, LEU, O 2.91Å
B, 230, ALA, HA A, 229, GLY, O 3.43Å
A, 226, LEU, HA B, 225, CYS, O 3.45Å
A, 229, GLY, HA1 B, 226, LEU, O 2.91Å
A, 230, ALA, HA B, 229, GLY, O 3.43Å