Sushi domain-containing protein 2

UniProt data

UniProt name: SUSD2_HUMAN (Q9UGT4)

Gene name: SUSD2

Organism: Homo sapiens (Human).

Function: May be a cytokine receptor for C10ORF99. May be a tumor suppressor; together with C10ORF99 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (PubMed:25351403). May play a role in breast tumorigenesis (PubMed:23131994). {ECO:0000269|PubMed:23131994, ECO:0000269|PubMed:25351403}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:23131994, ECO:0000269|PubMed:25351403}; Single-pass type I membrane protein {ECO:0000305}. Note=SUSD2 and LGALS1 co-localized in very specific, punctate regions along the cell membrane of breast cancer cells. {ECO:0000269|PubMed:23131994}.

Transmembrane domains:

  1. 786-806, 21 AA, Helical. {ECO:0000255}.

Sequence: 822 AA

10 20 30 40 50 60 MKPALLPWAL LLLATALGPG PGPTADAQES CSMRCGALDG PCSCHPTCSG LGTCCLDFRD 70 80 90 100 110 120 FCLEILPYSG SMMGGKDFVV RHFKMSSPTD ASVICRFKDS IQTLGHVDSS GQVHCVSPLL 130 140 150 160 170 180 YESGRIPFTV SLDNGHSFPR AGTWLAVHPN KVSMMEKSEL VNETRWQYYG TANTSGNLSL 190 200 210 220 230 240 TWHVKSLPTQ TITIELWGYE ETGMPYSQEW TAKWSYLYPL ATHIPNSGSF TFTPKPAPPS 250 260 270 280 290 300 YQRWRVGALR IIDSKNYAGQ KDVQALWTND HALAWHLSDD FREDPVAWAR TQCQAWEELE 310 320 330 340 350 360 DQLPNFLEEL PDCPCTLTQA RADSGRFFTD YGCDMEQGSV CTYHPGAVHC VRSVQASLRY 370 380 390 400 410 420 GSGQQCCYTA DGTQLLTADS SGGSTPDRGH DWGAPPFRTP PRVPSMSHWL YDVLSFYYCC 430 440 450 460 470 480 LWAPDCPRYM QRRPSNDCRN YRPPRLASAF GDPHFVTFDG TNFTFNGRGE YVLLEAALTD 490 500 510 520 530 540 LRVQARAQPG TMSNGTETRG TGLTAVAVQE GNSDVVEVRL ANRTGGLEVL LNQEVLSFTE 550 560 570 580 590 600 QSWMDLKGMF LSVAAGDRVS IMLASGAGLE VSVQGPFLSV SVLLPEKFLT HTHGLLGTLN 610 620 630 640 650 660 NDPTDDFTLH SGRVLPPGTS PQELFLFGAN WTVHNASSLL TYDSWFLVHN FLYQPKHDPT 670 680 690 700 710 720 FEPLFPSETT LNPSLAQEAA KLCGDDHFCN FDVAATGSLS TGTATRVAHQ LHQRRMQSLQ 730 740 750 760 770 780 PVVSCGWLAP PPNGQKEGNR YLAGSTIYFH CDNGYSLAGA ETSTCQADGT WSSPTPKCQP 790 800 810 820 GRSYAVLLGI IFGGLAVVAA VALVYVLLRR RKGNTHVWGA QP

CATM prediction

The sequence of SUSD2_HUMAN returned 4 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         790       800       
  +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 SYAVLLGIIFGGLAVVAAVALVYVLLR 6.5 -48.0° 0.7 54.1 -33.4
Model 2 SYAVLLGIIFGGLAVVAAVALVYVLLR 7.2 -51.0° 2.4 45.3 -30.1
Model 3 SYAVLLGIIFGGLAVVAAVALVYVLLR 7.4 -54.0° 3.6 49.0 -7.7
Model 4 SYAVLLGIIFGGLAVVAAVALVYVLLR 7.1 -33.6° 2.3 34.9 -3.3

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 789, GLY, HA1 A, 786, VAL, O 2.68Å
B, 790, ILE, HA A, 789, GLY, O 2.69Å
A, 789, GLY, HA1 B, 786, VAL, O 2.68Å
A, 790, ILE, HA B, 789, GLY, O 2.69Å