Ephrin type-A receptor 6

UniProt data

UniProt name: EPHA6_HUMAN (Q9UF33)

Gene name: EPHA6; Synonyms=EHK2, HEK12

Organism: Homo sapiens (Human).

Function: Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity). {ECO:0000250}.

Subcellular location: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Transmembrane domains:

  1. 551-571, 21 AA, Helical. {ECO:0000255}.

Sequence: 1036 AA

10 20 30 40 50 60 MGGCEVREFL LQFGFFLPLL TAWPGDCSHV SNNQVVLLDT TTVLGELGWK TYPLNGWDAI 70 80 90 100 110 120 TEMDEHNRPI HTYQVCNVME PNQNNWLRTN WISRDAAQKI YVEMKFTLRD CNSIPWVLGT 130 140 150 160 170 180 CKETFNLFYM ESDESHGIKF KPNQYTKIDT IAADESFTQM DLGDRILKLN TEIREVGPIE 190 200 210 220 230 240 RKGFYLAFQD IGACIALVSV RVFYKKCPFT VRNLAMFPDT IPRVDSSSLV EVRGSCVKSA 250 260 270 280 290 300 EERDTPKLYC GADGDWLVPL GRCICSTGYE EIEGSCHACR PGFYKAFAGN TKCSKCPPHS 310 320 330 340 350 360 LTYMEATSVC QCEKGYFRAE KDPPSMACTR PPSAPRNVVF NINETALILE WSPPSDTGGR 370 380 390 400 410 420 KDLTYSVICK KCGLDTSQCE DCGGGLRFIP RHTGLINNSV IVLDFVSHVN YTFEIEAMNG 430 440 450 460 470 480 VSELSFSPKP FTAITVTTDQ DAPSLIGVVR KDWASQNSIA LSWQAPAFSN GAILDYEIKY 490 500 510 520 530 540 YEKEHEQLTY SSTRSKAPSV IITGLKPATK YVFHIRVRTA TGYSGYSQKF EFETGDETSD 550 560 570 580 590 600 MAAEQGQILV IATAAVGGFT LLVILTLFFL ITGRCQWYIK AKMKSEEKRR NHLQNGHLRF 610 620 630 640 650 660 PGIKTYIDPD TYEDPSLAVH EFAKEIDPSR IRIERVIGAG EFGEVCSGRL KTPGKREIPV 670 680 690 700 710 720 AIKTLKGGHM DRQRRDFLRE ASIMGQFDHP NIIRLEGVVT KRSFPAIGVE AFCPSFLRAG 730 740 750 760 770 780 FLNSIQAPHP VPGGGSLPPR IPAGRPVMIV VEYMENGSLD SFLRKHDGHF TVIQLVGMLR 790 800 810 820 830 840 GIASGMKYLS DMGYVHRDLA ARNILVNSNL VCKVSDFGLS RVLEDDPEAA YTTTGGKIPI 850 860 870 880 890 900 RWTAPEAIAY RKFSSASDAW SYGIVMWEVM SYGERPYWEM SNQDVILSIE EGYRLPAPMG 910 920 930 940 950 960 CPASLHQLML HCWQKERNHR PKFTDIVSFL DKLIRNPSAL HTLVEDILVM PESPGEVPEY 970 980 990 1000 1010 1020 PLFVTVGDWL DSIKMGQYKN NFVAAGFTTF DLISRMSIDD IRRIGVILIG HQRRIVSSIQ 1030 TLRLHMMHIQ EKGFHV

CATM prediction

The sequence of EPHA6_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    550       560       570  
  |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 ILVIATAAVGGFTLLVILTLFFLITGR 6.9 -53.9° 2.6 33.0 -14.2

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 554, ALA, HA A, 553, THR, O 3.30Å
B, 557, GLY, HA1 A, 554, ALA, O 3.02Å
A, 554, ALA, HA B, 553, THR, O 3.30Å
A, 557, GLY, HA1 B, 554, ALA, O 3.02Å