Vesicle transport through interaction with t-SNAREs homolog 1B

UniProt data

UniProt name: VTI1B_HUMAN (Q9UEU0)

Gene name: VTI1B; Synonyms=VTI1, VTI1L, VTI1L1, VTI2

Organism: Homo sapiens (Human).

Function: V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence.

Subcellular location: Late endosome membrane {ECO:0000269|PubMed:23217709}; Single-pass type IV membrane protein {ECO:0000269|PubMed:23217709}. Lysosome membrane {ECO:0000269|PubMed:23217709}. Cytoplasmic granule {ECO:0000269|PubMed:23217709}.

Transmembrane domains:

  1. 209-229, 21 AA, Helical; Anchor for type IV membrane protein. {ECO:0000255}.

Sequence: 232 AA

10 20 30 40 50 60 MASSAASSEH FEKLHEIFRG LHEDLQGVPE RLLGTAGTEE KKKLIRDFDE KQQEANETLA 70 80 90 100 110 120 EMEEELRYAP LSFRNPMMSK LRNYRKDLAK LHREVRSTPL TATPGGRGDM KYGIYAVENE 130 140 150 160 170 180 HMNRLQSQRA MLLQGTESLN RATQSIERSH RIATETDQIG SEIIEELGEQ RDQLERTKSR 190 200 210 220 230 LVNTSENLSK SRKILRSMSR KVTTNKLLLS IIILLELAIL GGLVYYKFFR SH

CATM prediction

The sequence of VTI1B_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      210       220       230
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 KLLLSIIILLELAILGGLVYYKFFRSH 7.3 -54.6° 3.6 48.8 -10.5

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 219, ILE, HA A, 218, ALA, O 3.26Å
B, 222, GLY, HA1 A, 219, ILE, O 3.41Å
A, 219, ILE, HA B, 218, ALA, O 3.26Å
A, 222, GLY, HA1 B, 219, ILE, O 3.41Å