Protein sel-1 homolog 1

UniProt data

UniProt name: SE1L1_HUMAN (Q9UBV2)

Gene name: SEL1L; Synonyms=TSA305; ORFNames=UNQ128/PRO1063

Organism: Homo sapiens (Human).

Function: Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:16186509). Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells. May play a role in Notch signaling. {ECO:0000250|UniProtKB:Q9Z2G6, ECO:0000269|PubMed:16186509}.

Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16186509}; Single-pass type I membrane protein {ECO:0000269|PubMed:16186509}.

Transmembrane domains:

  1. 739-759, 21 AA, Helical. {ECO:0000255}.

Sequence: 794 AA

10 20 30 40 50 60 MRVRIGLTLL LCAVLLSLAS ASSDEEGSQD ESLDSKTTLT SDESVKDHTT AGRVVAGQIF 70 80 90 100 110 120 LDSEESELES SIQEEEDSLK SQEGESVTED ISFLESPNPE NKDYEEPKKV RKPALTAIEG 130 140 150 160 170 180 TAHGEPCHFP FLFLDKEYDE CTSDGREDGR LWCATTYDYK ADEKWGFCET EEEAAKRRQM 190 200 210 220 230 240 QEAEMMYQTG MKILNGSNKK SQKREAYRYL QKAASMNHTK ALERVSYALL FGDYLPQNIQ 250 260 270 280 290 300 AAREMFEKLT EEGSPKGQTA LGFLYASGLG VNSSQAKALV YYTFGALGGN LIAHMVLGYR 310 320 330 340 350 360 YWAGIGVLQS CESALTHYRL VANHVASDIS LTGGSVVQRI RLPDEVENPG MNSGMLEEDL 370 380 390 400 410 420 IQYYQFLAEK GDVQAQVGLG QLHLHGGRGV EQNHQRAFDY FNLAANAGNS HAMAFLGKMY 430 440 450 460 470 480 SEGSDIVPQS NETALHYFKK AADMGNPVGQ SGLGMAYLYG RGVQVNYDLA LKYFQKAAEQ 490 500 510 520 530 540 GWVDGQLQLG SMYYNGIGVK RDYKQALKYF NLASQGGHIL AFYNLAQMHA SGTGVMRSCH 550 560 570 580 590 600 TAVELFKNVC ERGRWSERLM TAYNSYKDGD YNAAVIQYLL LAEQGYEVAQ SNAAFILDQR 610 620 630 640 650 660 EASIVGENET YPRALLHWNR AASQGYTVAR IKLGDYHFYG FGTDVDYETA FIHYRLASEQ 670 680 690 700 710 720 QHSAQAMFNL GYMHEKGLGI KQDIHLAKRF YDMAAEASPD AQVPVFLALC KLGVVYFLQY 730 740 750 760 770 780 IRETNIRDMF TQLDMDQLLG PEWDLYLMTI IALLLGTVIA YRQRQHQDMP APRPPGPRPA 790 PPQQEGPPEQ QPPQ

CATM prediction

The sequence of SE1L1_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      740       750       760
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 DQLLGAEWDLYLMTIIALLLGTVIAYR 7.1 -38.0° 5.7 34.3 -17.9
Model 2 DQLLGAEWDLYLMTIIALLLGTVIAYR 6.9 -51.7° 1.3 56.9 -9.1
Model 3 DQLLGAEWDLYLMTIIALLLGTVIAYR 7.2 -40.0° 5.1 43.6 -2.0
Prolines* DQLLGPEWDLYLMTIIALLLGTVIAYR          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 753, LEU, HA A, 752, ALA, O 2.96Å
B, 756, GLY, HA1 A, 753, LEU, O 3.30Å
A, 753, LEU, HA B, 752, ALA, O 2.96Å
A, 756, GLY, HA1 B, 753, LEU, O 3.30Å