Exostosin-like 2

UniProt data

UniProt name: EXTL2_HUMAN (Q9UBQ6)

Gene name: EXTL2; Synonyms=EXTR2

Organism: Homo sapiens (Human).

Function: Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N- acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains. {ECO:0000269|PubMed:10318803}.

Subcellular location: Processed exostosin-like 2: Secreted. Note=A soluble form is found in the serum.

Transmembrane domains:

  1. 23-43, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 330 AA

10 20 30 40 50 60 MRCCHICKLP GRVMGIRVLR LSLVVILVLL LVAGALTALL PSVKEDKMLM LRREIKSQGK 70 80 90 100 110 120 STMDSFTLIM QTYNRTDLLL KLLNHYQAVP NLHKVIVVWN NIGEKAPDEL WNSLGPHPIP 130 140 150 160 170 180 VIFKQQTANR MRNRLQVFPE LETNAVLMVD DDTLISTPDL VFAFSVWQQF PDQIVGFVPR 190 200 210 220 230 240 KHVSTSSGIY SYGSFEMQAP GSGNGDQYSM VLIGASFFNS KYLELFQRQP AAVHALIDDT 250 260 270 280 290 300 QNCDDIAMNF IIAKHIGKTS GIFVKPVNMD NLEKETNSGY SGMWHRAEHA LQRSYCINKL 310 320 VNIYDSMPLR YSNIMISQFG FPYANYKRKI

CATM prediction

The sequence of EXTL2_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  20        30        40     
|    +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 RLSLVVILVLLLVAGALTALLASVKED 7.3 -45.0° 0.1 45.1 -0.3
Prolines* RLSLVVILVLLLVAGALTALLPSVKED          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 34, GLY, HA1 A, 31, LEU, O 3.39Å
B, 35, ALA, HA A, 34, GLY, O 3.26Å
A, 34, GLY, HA1 B, 31, LEU, O 3.39Å
A, 35, ALA, HA B, 34, GLY, O 3.26Å