Neurexin-2

UniProt data

UniProt name: NRX2A_HUMAN (Q9P2S2)

Gene name: NRXN2; Synonyms=KIAA0921

Organism: Homo sapiens (Human).

Function: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 1637-1657, 21 AA, Helical. {ECO:0000255}.

Sequence: 1712 AA

10 20 30 40 50 60 MASGSRWRPT PPPLLLLLLL ALAARADGLE FGGGPGQWAR YARWAGAASS GELSFSLRTN 70 80 90 100 110 120 ATRALLLYLD DGGDCDFLEL LLVDGRLRLR FTLSCAEPAT LQLDTPVADD RWHMVLLTRD 130 140 150 160 170 180 ARRTALAVDG EARAAEVRSK RREMQVASDL FVGGIPPDVR LSALTLSTVK YEPPFRGLLA 190 200 210 220 230 240 NLKLGERPPA LLGSQGLRGA TADPLCAPAR NPCANGGLCT VLAPGEVGCD CSHTGFGGKF 250 260 270 280 290 300 CSEEEHPMEG PAHLTLNSEV GSLLFSEGGA GRGGAGDVHQ PTKGKEEFVA TFKGNEFFCY 310 320 330 340 350 360 DLSHNPIQSS TDEITLAFRT LQRNGLMLHT GKSADYVNLS LKSGAVWLVI NLGSGAFEAL 370 380 390 400 410 420 VEPVNGKFND NAWHDVRVTR NLRQHAGIGH AMVNKLHYLV TISVDGILTT TGYTQEDYTM 430 440 450 460 470 480 LGSDDFFYIG GSPNTADLPG SPVSNNFMGC LKDVVYKNND FKLELSRLAK EGDPKMKLQG 490 500 510 520 530 540 DLSFRCEDVA ALDPVTFESP EAFVALPRWS AKRTGSISLD FRTTEPNGLL LFSQGRRAGG 550 560 570 580 590 600 GAGSHSSAQR ADYFAMELLD GHLYLLLDMG SGGIKLRASS RKVNDGEWCH VDFQRDGRKG 610 620 630 640 650 660 SISVNSRSTP FLATGDSEIL DLESELYLGG LPEGGRVDLP LPPEVWTAAL RAGYVGCVRD 670 680 690 700 710 720 LFIDGRSRDL RGLAEAQGAV GVAPFCSRET LKQCASAPCR NGGVCREGWN RFICDCIGTG 730 740 750 760 770 780 FLGRVCEREA TVLSYDGSMY MKIMLPNAMH TEAEDVSLRF MSQRAYGLMM ATTSRESADT 790 800 810 820 830 840 LRLELDGGQM KLTVNLDCLR VGCAPSKGPE TLFAGHKLND NEWHTVRVVR RGKSLQLSVD 850 860 870 880 890 900 NVTVEGQMAG AHMRLEFHNI ETGIMTERRF ISVVPSNFIG HLSGLVFNGQ PYMDQCKDGD 910 920 930 940 950 960 ITYCELNARF GLRAIVADPV TFKSRSSYLA LATLQAYASM HLFFQFKTTA PDGLLLFNSG 970 980 990 1000 1010 1020 NGNDFIVIEL VKGYIHYVFD LGNGPSLMKG NSDKPVNDNQ WHNVVVSRDP GNVHTLKIDS 1030 1040 1050 1060 1070 1080 RTVTQHSNGA RNLDLKGELY IGGLSKNMFS NLPKLVASRD GFQGCLASVD LNGRLPDLIA 1090 1100 1110 1120 1130 1140 DALHRIGQVE RGCDGPSTTC TEESCANQGV CLQQWDGFTC DCTMTSYGGP VCNDPGTTYI 1150 1160 1170 1180 1190 1200 FGKGGALITY TWPPNDRPST RMDRLAVGFS THQRSAVLVR VDSASGLGDY LQLHIDQGTV 1210 1220 1230 1240 1250 1260 GVIFNVGTDD ITIDEPNAIV SDGKYHVVRF TRSGGNATLQ VDSWPVNERY PAGNFDNERL 1270 1280 1290 1300 1310 1320 AIARQRIPYR LGRVVDEWLL DKGRQLTIFN SQAAIKIGGR DQGRPFQGQV SGLYYNGLKV 1330 1340 1350 1360 1370 1380 LALAAESDPN VRTEGHLRLV GEGPSVLLSA ETTATTLLAD MATTIMETTT TMATTTTRRG 1390 1400 1410 1420 1430 1440 RSPTLRDSTT QNTDDLLVAS AECPSDDEDL EECEPSTGGE LILPIITEDS LDPPPVATRS 1450 1460 1470 1480 1490 1500 PFVPPPPTFY PFLTGVGATQ DTLPPPAARR PPSGGPCQAE RDDSDCEEPI EASGFASGEV 1510 1520 1530 1540 1550 1560 FDSSLPPTDD EDFYTTFPLV TDRTTLLSPR KPAPRPNLRT DGATGAPGVL FAPSAPAPNL 1570 1580 1590 1600 1610 1620 PAGKMNHRDP LQPLLENPPL GPGAPTSFEP RRPPPLRPGV TSAPGFPHLP TANPTGPGER 1630 1640 1650 1660 1670 1680 GPPGAVEVIR ESSSTTGMVV GIVAAAALCI LILLYAMYKY RNRDEGSYQV DQSRNYISNS 1690 1700 1710 AQSNGAVVKE KAPAAPKTPS KAKKNKDKEY YV

CATM prediction

The sequence of NRX2A_HUMAN returned 4 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        1640      1650      1
 +    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 STTGMVVGIVAAAALCILILLYAMYKY 6.4 -47.1° 3.3 54.0 -30.2
Model 2 STTGMVVGIVAAAALCILILLYAMYKY 7.3 -27.0° 6.0 58.0 -24.2
Model 3 STTGMVVGIVAAAALCILILLYAMYKY 7.3 -37.0° 2.2 36.2 -20.3
Model 4 STTGMVVGIVAAAALCILILLYAMYKY 7.3 -36.0° 1.5 36.1 -1.3

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 1638, MET, HA A, 1637, GLY, O 2.41Å
B, 1641, GLY, HA1 A, 1638, MET, O 2.56Å
B, 1642, ILE, HA A, 1641, GLY, O 3.44Å
A, 1638, MET, HA B, 1637, GLY, O 2.41Å
A, 1641, GLY, HA1 B, 1638, MET, O 2.56Å
A, 1642, ILE, HA B, 1641, GLY, O 3.44Å