Protein turtle homolog A

UniProt data

UniProt name: TUTLA_HUMAN (Q9P2J2)

Gene name: IGSF9; Synonyms=IGSF9A, KIAA1355, NRT1

Organism: Homo sapiens (Human).

Function: Functions in dendrite outgrowth and synapse maturation. {ECO:0000250}.

Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Enriched at the excitatory synapses in mature neurons. {ECO:0000250}.

Transmembrane domains:

  1. 735-755, 21 AA, Helical. {ECO:0000255}.

Sequence: 1179 AA

10 20 30 40 50 60 MVWCLGLAVL SLVISQGADG RGKPEVVSVV GRAGESVVLG CDLLPPAGRP PLHVIEWLRF 70 80 90 100 110 120 GFLLPIFIQF GLYSPRIDPD YVGRVRLQKG ASLQIEGLRV EDQGWYECRV FFLDQHIPED 130 140 150 160 170 180 DFANGSWVHL TVNSPPQFQE TPPAVLEVQE LEPVTLRCVA RGSPLPHVTW KLRGKDLGQG 190 200 210 220 230 240 QGQVQVQNGT LRIRRVERGS SGVYTCQASS TEGSATHATQ LLVLGPPVIV VPPKNSTVNA 250 260 270 280 290 300 SQDVSLACHA EAYPANLTYS WFQDNINVFH ISRLQPRVRI LVDGSLRLLA TQPDDAGCYT 310 320 330 340 350 360 CVPSNGLLHP PSASAYLTVL YPAQVTAMPP ETPLPIGMPG VIRCPVRANP PLLFVSWTKD 370 380 390 400 410 420 GKALQLDKFP GWSQGTEGSL IIALGNEDAL GEYSCTPYNS LGTAGPSPVT RVLLKAPPAF 430 440 450 460 470 480 IERPKEEYFQ EVGRELLIPC SAQGDPPPVV SWTKVGRGLQ GQAQVDSNSS LILRPLTKEA 490 500 510 520 530 540 HGHWECSASN AVARVATSTN VYVLGTSPHV VTNVSVVALP KGANVSWEPG FDGGYLQRFS 550 560 570 580 590 600 VWYTPLAKRP DRMHHDWVSL AVPVGAAHLL VPGLQPHTQY QFSVLAQNKL GSGPFSEIVL 610 620 630 640 650 660 SAPEGLPTTP AAPGLPPTEI PPPLSPPRGL VAVRTPRGVL LHWDPPELVP KRLDGYVLEG 670 680 690 700 710 720 RQGSQGWEVL DPAVAGTETE LLVPGLIKDV LYEFRLVAFA GSFVSDPSNT ANVSTSGLEV 730 740 750 760 770 780 YPSRTQLPGL LPQPVLAGVV GGVCFLGVAV LVSILAGCLL NRRRAARRRR KRLRQDPPLI 790 800 810 820 830 840 FSPTGKSAAP SALGSGSPDS VAKLKLQGSP VPSLRQSLLW GDPAGTPSPH PDPPSSRGPL 850 860 870 880 890 900 PLEPICRGPD GRFVMGPTVA APQERSGREQ AEPRTPAQRL ARSFDCSSSS PSGAPQPLCI 910 920 930 940 950 960 EDISPVAPPP AAPPSPLPGP GPLLQYLSLP FFREMNVDGD WPPLEEPSPA APPDYMDTRR 970 980 990 1000 1010 1020 CPTSSFLRSP ETPPVSPRES LPGAVVGAGA TAEPPYTALA DWTLRERLLP GLLPAAPRGS 1030 1040 1050 1060 1070 1080 LTSQSSGRGS ASFLRPPSTA PSAGGSYLSP APGDTSSWAS GPERWPRREH VVTVSKRRNT 1090 1100 1110 1120 1130 1140 SVDENYEWDS EFPGDMELLE TLHLGLASSR LRPEAEPELG VKTPEEGCLL NTAHVTGPEA 1150 1160 1170 RCAALREEFL AFRRRRDATR ARLPAYRQPV PHPEQATLL

CATM prediction

The sequence of TUTLA_HUMAN returned 5 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          740       750      
   +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 AQAVLAGVVGGVCFLGVAVLVSILAGC 6.7 -43.1° 3.0 35.3 -28.1
Model 2 AQAVLAGVVGGVCFLGVAVLVSILAGC 6.9 -52.1° 1.4 56.9 -14.8
Model 3 AQAVLAGVVGGVCFLGVAVLVSILAGC 7.1 -53.9° 4.8 40.9 -8.9
Model 4 AQAVLAGVVGGVCFLGVAVLVSILAGC 7.3 -34.0° 3.3 51.0 -7.1
Model 5 AQAVLAGVVGGVCFLGVAVLVSILAGC 7.3 -34.0° 2.7 37.6 -3.1
Prolines* PQPVLAGVVGGVCFLGVAVLVSILAGC          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 738, GLY, HA2 A, 737, ALA, O 2.88Å
B, 741, GLY, HA1 A, 738, GLY, O 2.76Å
B, 742, GLY, HA2 A, 741, GLY, O 3.31Å
A, 738, GLY, HA2 B, 737, ALA, O 2.88Å
A, 741, GLY, HA1 B, 738, GLY, O 2.76Å
A, 742, GLY, HA2 B, 741, GLY, O 3.31Å