Ribosome-binding protein 1

UniProt data

UniProt name: RRBP1_HUMAN (Q9P2E9)

Gene name: RRBP1; Synonyms=KIAA1398

Organism: Homo sapiens (Human).

Function: Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane. {ECO:0000250}.

Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}.

Transmembrane domains:

  1. 8-28, 21 AA, Helical. {ECO:0000255}.

Sequence: 1410 AA

10 20 30 40 50 60 MDIYDTQTLG VVVFGGFMVV SAIGIFLVST FSMKETSYEE ALANQRKEMA KTHHQKVEKK 70 80 90 100 110 120 KKEKTVEKKG KTKKKEEKPN GKIPDHDPAP NVTVLLREPV RAPAVAVAPT PVQPPIIVAP 130 140 150 160 170 180 VATVPAMPQE KLASSPKDKK KKEKKVAKVE PAVSSVVNSI QVLTSKAAIL ETAPKEVPMV 190 200 210 220 230 240 VVPPVGAKGN TPATGTTQGK KAEGTQNQSK KAEGAPNQGR KAEGTPNQGK KTEGTPNQGK 250 260 270 280 290 300 KAEGTPNQGK KAEGTPNQGK KAEGAQNQGK KVDTTPNQGK KVEGAPTQGR KAEGAQNQAK 310 320 330 340 350 360 KVEGAQNQGK KAEGAQNQGK KGEGAQNQGK KAEGAQNQGK KAEGAQNQGK KAEGAQNQGK 370 380 390 400 410 420 KAEGAQNQGK KAEGAQNQGK KSEGAQNQGK KVEGAQNQGK KAEGAQNQGK KAEGAQNQGK 430 440 450 460 470 480 KAEGAQNQGK KAEGAQNQGK KAEGAQNQGK KAEGAQNQGK KAEGAQNQGK KVEGAQNQGK 490 500 510 520 530 540 KAEGAQNQGK KAEGAQNQGK KAEGAQNQGQ KGEGAQNQGK KTEGAQGKKA ERSPNQGKKG 550 560 570 580 590 600 EGAPIQGKKA DSVANQGTKV EGITNQGKKA EGSPSEGKKA EGSPNQGKKA DAAANQGKKT 610 620 630 640 650 660 ESASVQGRNT DVAQSPEAPK QEAPAKKKSG SKKKGEPGPP DADGPLYLPY KTLVSTVGSM 670 680 690 700 710 720 VFNEGEAQRL IEILSEKAGI IQDTWHKATQ KGDPVAILKR QLEEKEKLLA TEQEDAAVAK 730 740 750 760 770 780 SKLRELNKEM AAEKAKAAAG EAKVKKQLVA REQEITAVQA RMQASYREHV KEVQQLQGKI 790 800 810 820 830 840 RTLQEQLENG PNTQLARLQQ ENSILRDALN QATSQVESKQ NAELAKLRQE LSKVSKELVE 850 860 870 880 890 900 KSEAVRQDEQ QRKALEAKAA AFEKQVLQLQ ASHRESEEAL QKRLDEVSRE LCHTQSSHAS 910 920 930 940 950 960 LRADAEKAQE QQQQMAELHS KLQSSEAEVR SKCEELSGLH GQLQEARAEN SQLTERIRSI 970 980 990 1000 1010 1020 EALLEAGQAR DAQDVQASQA EADQQQTRLK ELESQVSGLE KEAIELREAV EQQKVKNNDL 1030 1040 1050 1060 1070 1080 REKNWKAMEA LATAEQACKE KLLSLTQAKE ESEKQLCLIE AQTMEALLAL LPELSVLAQQ 1090 1100 1110 1120 1130 1140 NYTEWLQDLK EKGPTLLKHP PAPAEPSSDL ASKLREAEET QSTLQAECDQ YRSILAETEG 1150 1160 1170 1180 1190 1200 MLRDLQKSVE EEEQVWRAKV GAAEEELQKS RVTVKHLEEI VEKLKGELES SDQVREHTSH 1210 1220 1230 1240 1250 1260 LEAELEKHMA AASAECQNYA KEVAGLRQLL LESQSQLDAA KSEAQKQSDE LALVRQQLSE 1270 1280 1290 1300 1310 1320 MKSHVEDGDI AGAPASSPEA PPAEQDPVQL KTQLEWTEAI LEDEQTQRQK LTAEFEEAQT 1330 1340 1350 1360 1370 1380 SACRLQEELE KLRTAGPLES SETEEASQLK ERLEKEKKLT SDLGRAATRL QELLKTTQEQ 1390 1400 LAREKDTVKK LQEQLEKAED GSSSKEGTSV

CATM prediction

The sequence of RRBP1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       10        20        30
+    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 DTQTLGVVVFGGFMVVSAIGIFLVSTF 7.4 -54.0° 3.6 35.0 -2.9

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session