Prostaglandin F2 receptor negative regulator

UniProt data

UniProt name: FPRP_HUMAN (Q9P2B2)

Gene name: PTGFRN; Synonyms=CD9P1, EWIF, FPRP, KIAA1436

Organism: Homo sapiens (Human).

Function: Inhibits the binding of prostaglandin F2-alpha (PGF2- alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur (By similarity). {ECO:0000250}.

Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Transmembrane domains:

  1. 833-853, 21 AA, Helical. {ECO:0000255}.

Sequence: 879 AA

10 20 30 40 50 60 MGRLASRPLL LALLSLALCR GRVVRVPTAT LVRVVGTELV IPCNVSDYDG PSEQNFDWSF 70 80 90 100 110 120 SSLGSSFVEL ASTWEVGFPA QLYQERLQRG EILLRRTAND AVELHIKNVQ PSDQGHYKCS 130 140 150 160 170 180 TPSTDATVQG NYEDTVQVKV LADSLHVGPS ARPPPSLSLR EGEPFELRCT AASASPLHTH 190 200 210 220 230 240 LALLWEVHRG PARRSVLALT HEGRFHPGLG YEQRYHSGDV RLDTVGSDAY RLSVSRALSA 250 260 270 280 290 300 DQGSYRCIVS EWIAEQGNWQ EIQEKAVEVA TVVIQPSVLR AAVPKNVSVA EGKELDLTCN 310 320 330 340 350 360 ITTDRADDVR PEVTWSFSRM PDSTLPGSRV LARLDRDSLV HSSPHVALSH VDARSYHLLV 370 380 390 400 410 420 RDVSKENSGY YYCHVSLWAP GHNRSWHKVA EAVSSPAGVG VTWLEPDYQV YLNASKVPGF 430 440 450 460 470 480 ADDPTELACR VVDTKSGEAN VRFTVSWYYR MNRRSDNVVT SELLAVMDGD WTLKYGERSK 490 500 510 520 530 540 QRAQDGDFIF SKEHTDTFNF RIQRTTEEDR GNYYCVVSAW TKQRNNSWVK SKDVFSKPVN 550 560 570 580 590 600 IFWALEDSVL VVKARQPKPF FAAGNTFEMT CKVSSKNIKS PRYSVLIMAE KPVGDLSSPN 610 620 630 640 650 660 ETKYIISLDQ DSVVKLENWT DASRVDGVVL EKVQEDEFRY RMYQTQVSDA GLYRCMVTAW 670 680 690 700 710 720 SPVRGSLWRE AATSLSNPIE IDFQTSGPIF NASVHSDTPS VIRGDLIKLF CIITVEGAAL 730 740 750 760 770 780 DPDDMAFDVS WFAVHSFGLD KAPVLLSSLD RKGIVTTSRR DWKSDLSLER VSVLEFLLQV 790 800 810 820 830 840 HGSEDQDFGN YYCSVTPWVK SPTGSWQKEA EIHSKPVFIT VKMDVLNAFK YPLLIGVGLS 850 860 870 TVIGLLSCLI GYCSSHWCCK KEVQETRRER RRLMSMEMD

CATM prediction

The sequence of FPRP_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  830       840       850    
|    +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 KYALLIGVGLSTVIGLLSCLIGYCSSH 7.0 -50.0° 2.9 46.9 -6.1
Model 2 KYALLIGVGLSTVIGLLSCLIGYCSSH 7.1 -37.6° 5.8 33.6 -4.1
Model 3 KYALLIGVGLSTVIGLLSCLIGYCSSH 7.0 -36.8° -0.0 37.0 -2.3
Prolines* KYPLLIGVGLSTVIGLLSCLIGYCSSH          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 837, VAL, HA A, 840, SER, OG 3.32Å
B, 841, THR, HA A, 840, SER, O 3.03Å
B, 844, GLY, HA1 A, 841, THR, O 3.01Å
B, 849, LEU, HA A, 852, TYR, OH 2.45Å
A, 837, VAL, HA B, 840, SER, OG 3.32Å
A, 841, THR, HA B, 840, SER, O 3.03Å
A, 844, GLY, HA1 B, 841, THR, O 3.01Å