UniProt data
UniProt name: SEM5B_HUMAN (Q9P283)
Gene name: SEMA5B; Synonyms=KIAA1445, SEMAG; ORFNames=UNQ5867/PRO34001
Organism: Homo sapiens (Human).
Function: May act as positive axonal guidance cues. {ECO:0000250}.
Subcellular location: Membrane; Single-pass type III membrane protein.
Transmembrane domains:
- 1037-1057, 21 AA, Helical; Signal-anchor for type III membrane protein. {ECO:0000255}.
Sequence: 1151 AA
10 20 30 40 50 60
MPCGFSPSPV AHHLVPGPPD TPAQQLRCGW TVGGWLLSLV RGLLPCLPPG ARTAEGPIMV
70 80 90 100 110 120
LAGPLAVSLL LPSLTLLVSH LSSSQDVSSE PSSEQQLCAL SKHPTVAFED LQPWVSNFTY
130 140 150 160 170 180
PGARDFSQLA LDPSGNQLIV GARNYLFRLS LANVSLLQAT EWASSEDTRR SCQSKGKTEE
190 200 210 220 230 240
ECQNYVRVLI VAGRKVFMCG TNAFSPMCTS RQVGNLSRTI EKINGVARCP YDPRHNSTAV
250 260 270 280 290 300
ISSQGELYAA TVIDFSGRDP AIYRSLGSGP PLRTAQYNSK WLNEPNFVAA YDIGLFAYFF
310 320 330 340 350 360
LRENAVEHDC GRTVYSRVAR VCKNDVGGRF LLEDTWTTFM KARLNCSRPG EVPFYYNELQ
370 380 390 400 410 420
SAFHLPEQDL IYGVFTTNVN SIAASAVCAF NLSAISQAFN GPFRYQENPR AAWLPIANPI
430 440 450 460 470 480
PNFQCGTLPE TGPNENLTER SLQDAQRLFL MSEAVQPVTP EPCVTQDSVR FSHLVVDLVQ
490 500 510 520 530 540
AKDTLYHVLY IGTESGTILK ALSTASRSLH GCYLEELHVL PPGRREPLRS LRILHSARAL
550 560 570 580 590 600
FVGLRDGVLR VPLERCAAYR SQGACLGARD PYCGWDGKQQ RCSTLEDSSN MSLWTQNITA
610 620 630 640 650 660
CPVRNVTRDG GFGPWSPWQP CEHLDGDNSG SCLCRARSCD SPRPRCGGLD CLGPAIHIAN
670 680 690 700 710 720
CSRNGAWTPW SSWALCSTSC GIGFQVRQRS CSNPAPRHGG RICVGKSREE RFCNENTPCP
730 740 750 760 770 780
VPIFWASWGS WSKCSSNCGG GMQSRRRACE NGNSCLGCGV EFKTCNPEGC PEVRRNTPWT
790 800 810 820 830 840
PWLPVNVTQG GARQEQRFRF TCRAPLADPH GLQFGRRRTE TRTCPADGSG SCDTDALVEV
850 860 870 880 890 900
LLRSGSTSPH TVSGGWAAWG PWSSCSRDCE LGFRVRKRTC TNPEPRNGGL PCVGDAAEYQ
910 920 930 940 950 960
DCNPQACPVR GAWSCWTSWS PCSASCGGGH YQRTRSCTSP APSPGEDICL GLHTEEALCA
970 980 990 1000 1010 1020
TQACPEGWSP WSEWSKCTDD GAQSRSRHCE ELLPGSSACA GNSSQSRPCP YSEIPVILPA
1030 1040 1050 1060 1070 1080
SSMEEATDCA GFNLIHLVAT GISCFLGSGL LTLAVYLSCQ HCQRQSQEST LVHPATPNHL
1090 1100 1110 1120 1130 1140
HYKGGGTPKN EKYTPMEFKT LNKNNLIPDD RANFYPLQQT NVYTTTYYPS PLNKHSFRPE
1150
ASPGQRCFPN S
CATM prediction
The sequence of SEM5B_HUMAN returned 1 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 1040 1050 1 + | + | + | |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | LIHLVATGISCFLGSGLLTLAVYLSCQ | 7.3 | -54.1° | 3.6 | 35.0 | -12.5 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 1044, CYS, HA | A, 1043, SER, O | 3.39Å |
| B, 1047, GLY, HA1 | A, 1044, CYS, O | 3.37Å |
| A, 1044, CYS, HA | B, 1043, SER, O | 3.39Å |
| A, 1047, GLY, HA1 | B, 1044, CYS, O | 3.37Å |