Leucine-rich repeat and fibronectin type III domain-containing protein 1

UniProt data

UniProt name: LRFN1_HUMAN (Q9P244)

Gene name: LRFN1; Synonyms=KIAA1484, SALM2

Organism: Homo sapiens (Human).

Function: Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1 (By similarity). {ECO:0000250}.

Subcellular location: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Note=Detected in excitatory, but not inhibitory, synaptic plasma membrane. {ECO:0000250}.

Transmembrane domains:

  1. 537-557, 21 AA, Helical. {ECO:0000255}.

Sequence: 771 AA

10 20 30 40 50 60 MAPGPFSSAL LSPPPAALPF LLLLWAGASR GQPCPGRCIC QNVAPTLTML CAKTGLLFVP 70 80 90 100 110 120 PAIDRRVVEL RLTDNFIAAV RRRDFANMTS LVHLTLSRNT IGQVAAGAFA DLRALRALHL 130 140 150 160 170 180 DSNRLAEVRG DQLRGLGNLR HLILGNNQIR RVESAAFDAF LSTVEDLDLS YNNLEALPWE 190 200 210 220 230 240 AVGQMVNLNT LTLDHNLIDH IAEGTFVQLH KLVRLDMTSN RLHKLPPDGL FLRSQGTGPK 250 260 270 280 290 300 PPTPLTVSFG GNPLHCNCEL LWLRRLTRED DLETCATPEH LTDRYFWSIP EEEFLCEPPL 310 320 330 340 350 360 ITRQAGGRAL VVEGQAVSLR CRAVGDPEPV VHWVAPDGRL LGNSSRTRVR GDGTLDVTIT 370 380 390 400 410 420 TLRDSGTFTC IASNAAGEAT APVEVCVVPL PLMAPPPAAP PPLTEPGSSD IATPGRPGAN 430 440 450 460 470 480 DSAAERRLVA AELTSNSVLI RWPAQRPVPG IRMYQVQYNS SVDDSLVYRM IPSTSQTFLV 490 500 510 520 530 540 NDLAAGRAYD LCVLAVYDDG ATALPATRVV GCVQFTTAGD PAPCRPLRAH FLGGTMIIAI 550 560 570 580 590 600 GGVIVASVLV FIVLLMIRYK VYGDGDSRRV KGSRSLPRVS HVCSQTNGAG TGAAQAPALP 610 620 630 640 650 660 AQDHYEALRE VESQAAPAVA VEAKAMEAET ASAEPEVVLG RSLGGSATSL CLLPSEETSG 670 680 690 700 710 720 EESRAAVGPR RSRSGALEPP TSAPPTLALV PGGAAARPRP QQRYSFDGDY GALFQSHSYP 730 740 750 760 770 RRARRTKRHR STPHLDGAGG GAAGEDGDLG LGSARACLAF TSTEWMLEST V

CATM prediction

The sequence of LRFN1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        540       550       5
 +    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 GTMIIAIGGVIVASVLVFIVLLMIRYK 7.2 -44.2° 1.8 45.2 -15.9

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 539, ALA, HA A, 538, ILE, O 3.40Å
B, 542, GLY, HA1 A, 539, ALA, O 3.18Å
B, 543, VAL, HA A, 542, GLY, O 3.43Å
A, 539, ALA, HA B, 538, ILE, O 3.40Å
A, 542, GLY, HA1 B, 539, ALA, O 3.18Å
A, 543, VAL, HA B, 542, GLY, O 3.43Å