Signal-regulatory protein gamma

UniProt data

UniProt name: SIRPG_HUMAN (Q9P1W8)

Gene name: SIRPG; Synonyms=SIRPB2

Organism: Homo sapiens (Human).

Function: Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T- cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation. {ECO:0000269|PubMed:15383453}.

Subcellular location: Membrane {ECO:0000269|PubMed:15383453}; Single-pass type I membrane protein {ECO:0000269|PubMed:15383453}.

Transmembrane domains:

  1. 361-383, 23 AA, Helical. {ECO:0000255}.

Sequence: 387 AA

10 20 30 40 50 60 MPVPASWPHP PGPFLLLTLL LGLTEVAGEE ELQMIQPEKL LLVTVGKTAT LHCTVTSLLP 70 80 90 100 110 120 VGPVLWFRGV GPGRELIYNQ KEGHFPRVTT VSDLTKRNNM DFSIRISSIT PADVGTYYCV 130 140 150 160 170 180 KFRKGSPENV EFKSGPGTEM ALGAKPSAPV VLGPAARTTP EHTVSFTCES HGFSPRDITL 190 200 210 220 230 240 KWFKNGNELS DFQTNVDPTG QSVAYSIRST ARVVLDPWDV RSQVICEVAH VTLQGDPLRG 250 260 270 280 290 300 TANLSEAIRV PPTLEVTQQP MRVGNQVNVT CQVRKFYPQS LQLTWSENGN VCQRETASTL 310 320 330 340 350 360 TENKDGTYNW TSWFLVNISD QRDDVVLTCQ VKHDGQLAVS KRLALEVTVH QKDQSSDATP 370 380 GPASSLTALL LIAVLLGPIY VPWKQKT

CATM prediction

The sequence of SIRPG_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    360       370       380    
  |    +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 ATAGAASSLTALLLIAVLLGAIYVAWKQK 7.1 -51.3° 3.3 48.0 -14.8
Prolines* ATPGPASSLTALLLIAVLLGPIYVPWKQK          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 374, VAL, HA A, 373, ALA, O 3.07Å
B, 377, GLY, HA1 A, 374, VAL, O 3.15Å
A, 374, VAL, HA B, 373, ALA, O 3.07Å
A, 377, GLY, HA1 B, 374, VAL, O 3.15Å