Disintegrin and metalloproteinase domain-containing protein 22

UniProt data

UniProt name: ADA22_HUMAN (Q9P0K1)

Gene name: ADAM22; Synonyms=MDC2

Organism: Homo sapiens (Human).

Function: Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein (PubMed:19692335). Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1. {ECO:0000269|PubMed:12589811, ECO:0000269|PubMed:15882968, ECO:0000269|PubMed:16385342, ECO:0000269|PubMed:19692335}.

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, axon {ECO:0000250|UniProtKB:Q9R1V6}.

Transmembrane domains:

  1. 737-757, 21 AA, Helical. {ECO:0000255}.

Sequence: 906 AA

10 20 30 40 50 60 MQAAVAVSVP FLLLCVLGTC PPARCGQAGD ASLMELEKRK ENRFVERQSI VPLRLIYRSG 70 80 90 100 110 120 GEDESRHDAL DTRVRGDLGG PQLTHVDQAS FQVDAFGTSF ILDVVLNHDL LSSEYIERHI 130 140 150 160 170 180 EHGGKTVEVK GGEHCYYQGH IRGNPDSFVA LSTCHGLHGM FYDGNHTYLI EPEENDTTQE 190 200 210 220 230 240 DFHFHSVYKS RLFEFSLDDL PSEFQQVNIT PSKFILKPRP KRSKRQLRRY PRNVEEETKY 250 260 270 280 290 300 IELMIVNDHL MFKKHRLSVV HTNTYAKSVV NMADLIYKDQ LKTRIVLVAM ETWATDNKFA 310 320 330 340 350 360 ISENPLITLR EFMKYRRDFI KEKSDAVHLF SGSQFESSRS GAAYIGGICS LLKGGGVNEF 370 380 390 400 410 420 GKTDLMAVTL AQSLAHNIGI ISDKRKLASG ECKCEDTWSG CIMGDTGYYL PKKFTQCNIE 430 440 450 460 470 480 EYHDFLNSGG GACLFNKPSK LLDPPECGNG FIETGEECDC GTPAECVLEG AECCKKCTLT 490 500 510 520 530 540 QDSQCSDGLC CKKCKFQPMG TVCREAVNDC DIRETCSGNS SQCAPNIHKM DGYSCDGVQG 550 560 570 580 590 600 ICFGGRCKTR DRQCKYIWGQ KVTASDKYCY EKLNIEGTEK GNCGKDKDTW IQCNKRDVLC 610 620 630 640 650 660 GYLLCTNIGN IPRLGELDGE ITSTLVVQQG RTLNCSGGHV KLEEDVDLGY VEDGTPCGPQ 670 680 690 700 710 720 MMCLEHRCLP VASFNFSTCL SSKEGTICSG NGVCSNELKC VCNRHWIGSD CNTYFPHNDD 730 740 750 760 770 780 AKTGITLSGN GVAGTNIIIG IIAGTILVLA LILGITAWGY KNYREQRQLP QGDYVKKPGD 790 800 810 820 830 840 GDSFYSDIPP GVSTNSASSS KKRSNGLSHS WSERIPDTKH ISDICENGRP RSNSWQGNLG 850 860 870 880 890 900 GNKKKIRGKR FRPRSNSTET LSPAKSPSSS TGSIASSRKY PYPMPPLPDE DKKVNRQSAR LWETSI

CATM prediction

The sequence of ADA22_HUMAN returned 4 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        740       750       7
 +    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 GTNIIIGIIAGTILVLALILGITAWGY 6.6 -48.1° 0.7 54.1 -29.9
Model 2 GTNIIIGIIAGTILVLALILGITAWGY 7.3 -51.2° 3.3 48.4 -14.5
Model 3 GTNIIIGIIAGTILVLALILGITAWGY 7.3 -54.7° 2.4 47.8 -2.6
Model 4 GTNIIIGIIAGTILVLALILGITAWGY 7.3 -54.0° 3.6 49.0 -1.9

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 740, GLY, HA1 A, 737, ILE, O 2.83Å
B, 741, ILE, HA A, 740, GLY, O 2.91Å
A, 740, GLY, HA1 B, 737, ILE, O 2.83Å
A, 741, ILE, HA B, 740, GLY, O 2.91Å