NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

UniProt data

UniProt name: NDUAD_HUMAN (Q9P0J0)

Gene name: NDUFA13; Synonyms=GRIM19; ORFNames=CDA016, CGI-39

Organism: Homo sapiens (Human).

Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes. {ECO:0000269|PubMed:12628925, ECO:0000269|PubMed:12867595, ECO:0000269|PubMed:15753091}.

Subcellular location: Mitochondrion inner membrane; Single-pass membrane protein; Matrix side. Nucleus. Note=May be translocated into the nucleus upon IFN/RA treatment.

Transmembrane domains:

  1. 30-51, 22 AA, Helical. {ECO:0000255}.

Sequence: 144 AA

10 20 30 40 50 60 MAASKVKQDM PPPGGYGPID YKRNLPRRGL SGYSMLAIGI GTLIYGHWSI MKWNRERRRL 70 80 90 100 110 120 QIEDFEARIA LLPLLQAETD RRTLQMLREN LEEEAIIMKD VPDWKVGESV FHTTRWVPPL 130 140 IGELYGLRTT EEALHASHGF MWYT

CATM prediction

The sequence of NDUAD_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     30        40        50   
   |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 RRGLSGYSMLAIGIGTLIYGHWSIMKWN 7.0 -50.0° 2.9 47.0 -14.6

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 38, ILE, HA A, 37, ALA, O 3.03Å
B, 41, GLY, HA1 A, 38, ILE, O 2.96Å
B, 46, GLY, HA2 A, 45, TYR, OH 3.17Å
A, 33, TYR, HH B, 34, SER, OG 2.01Å
A, 38, ILE, HA B, 37, ALA, O 3.03Å
A, 41, GLY, HA1 B, 38, ILE, O 2.96Å