Leucine-rich repeat transmembrane protein FLRT1

UniProt data

UniProt name: FLRT1_HUMAN (Q9NZU1)

Gene name: FLRT1; ORFNames=UNQ752/PRO1483

Organism: Homo sapiens (Human).

Function: Plays a role in fibroblast growth factor-mediated signaling cascades that lead to the activation of MAP kinases. Promotes neurite outgrowth via FGFR1-mediated activation of downstream MAP kinases. Promotes an increase both in neurite number and in neurite length. May play a role in cell-cell adhesion and cell guidance via its interaction with ADGRL1/LPHN1 and ADGRL3. {ECO:0000250|UniProtKB:Q6RKD8}.

Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q6RKD8}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q6RKD8}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q6RKD8}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q6RKD8}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q6RKD8}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q6RKD8}. Secreted {ECO:0000250|UniProtKB:Q6RKD8}. Cell projection {ECO:0000250|UniProtKB:Q6RKD8}. Cell junction {ECO:0000250|UniProtKB:Q6RKD8}. Note=In addition to its location at the cell membrane, colocalizes with FGFR1 in punctate perinuclear cytoplasmic vesicles. Detected along neurites and at contacts between neurite termini and other cells. Proteolytic cleavage gives rise to a shedded ectodomain. {ECO:0000250|UniProtKB:Q6RKD8}.

Transmembrane domains:

  1. 525-545, 21 AA, Helical. {ECO:0000255}.

Sequence: 646 AA

10 20 30 40 50 60 MDLRDWLFLC YGLIAFLTEV IDSTTCPSVC RCDNGFIYCN DRGLTSIPAD IPDDATTLYL 70 80 90 100 110 120 QNNQINNAGI PQDLKTKVNV QVIYLYENDL DEFPINLPRS LRELHLQDNN VRTIARDSLA 130 140 150 160 170 180 RIPLLEKLHL DDNSVSTVSI EEDAFADSKQ LKLLFLSRNH LSSIPSGLPH TLEELRLDDN 190 200 210 220 230 240 RISTIPLHAF KGLNSLRRLV LDGNLLANQR IADDTFSRLQ NLTELSLVRN SLAAPPLNLP 250 260 270 280 290 300 SAHLQKLYLQ DNAISHIPYN TLAKMRELER LDLSNNNLTT LPRGLFDDLG NLAQLLLRNN 310 320 330 340 350 360 PWFCGCNLMW LRDWVKARAA VVNVRGLMCQ GPEKVRGMAI KDITSEMDEC FETGPQGGVA 370 380 390 400 410 420 NAAAKTTASN HASATTPQGS LFTLKAKRPG LRLPDSNIDY PMATGDGAKT LAIHVKALTA 430 440 450 460 470 480 DSIRITWKAT LPASSFRLSW LRLGHSPAVG SITETLVQGD KTEYLLTALE PKSTYIICMV 490 500 510 520 530 540 TMETSNAYVA DETPVCAKAE TADSYGPTTT LNQEQNAGPM ASLPLAGIIG GAVALVFLFL 550 560 570 580 590 600 VLGAICWYVH QAGELLTRER AYNRGSRKKD DYMESGTKKD NSILEIRGPG LQMLPINPYR 610 620 630 640 AKEEYVVHTI FPSNGSSLCK ATHTIGYGTT RGYRDGGIPD IDYSYT

CATM prediction

The sequence of FLRT1_HUMAN returned 4 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          530       540      
   +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 SLALAGIIGGAVALVFLFLVLGAICWY 6.5 -55.2° 1.5 45.4 -22.6
Model 2 SLALAGIIGGAVALVFLFLVLGAICWY 7.3 -46.0° 3.6 37.0 -13.6
Model 3 SLALAGIIGGAVALVFLFLVLGAICWY 7.3 -30.0° 4.7 39.0 -13.5
Model 4 SLALAGIIGGAVALVFLFLVLGAICWY 7.4 -53.7° 3.6 49.1 -6.0
Prolines* SLPLAGIIGGAVALVFLFLVLGAICWY          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 527, GLY, HA2 A, 526, ALA, O 2.78Å
B, 530, GLY, HA1 A, 527, GLY, O 2.35Å
B, 531, GLY, HA2 A, 530, GLY, O 3.30Å
A, 527, GLY, HA2 B, 526, ALA, O 2.78Å
A, 530, GLY, HA1 B, 527, GLY, O 2.35Å
A, 531, GLY, HA2 B, 530, GLY, O 3.30Å