UniProt data
UniProt name: KLRF1_HUMAN (Q9NZS2)
Gene name: KLRF1; Synonyms=CLEC5C, ML
Organism: Homo sapiens (Human).
Function: Involved in the natural killer (NK)-mediated cytolysis of PHA-induced lymphoblasts.
Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Transmembrane domains:
- 39-59, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.
Sequence: 232 AA
10 20 30 40 50 60
MQDEERYMTL NVQSKKRSSA QTSQLTFKDY SVTLHWYKIL LGISGTVNGI LTLTLISLIL
70 80 90 100 110 120
LVSQGVLLKC QKGSCSNATQ YEDTGDLKVN NGTRRNISNK DLCASRSADQ TVLCQSEWLK
130 140 150 160 170 180
YQGKCCYWFS NEMKSWSDSY VYCLERKSHL LIIHDQLEMA FIQKNLRQLN YVWIGLNFTS
190 200 210 220 230
LKMTWTWVDG SPIDSKIFFI KGPAKENSCA AIKESKIFSE TCSSVFKWIC QY
CATM prediction
The sequence of KLRF1_HUMAN returned 3 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 40 50 60 | + | + | |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | WYKILLGISGTVNGILTLTLISLILLV | 7.2 | -51.0° | 3.3 | 48.1 | -31.1 |
| Model 2 | WYKILLGISGTVNGILTLTLISLILLV | 6.7 | -55.0° | 1.5 | 45.0 | -25.8 |
| Model 3 | WYKILLGISGTVNGILTLTLISLILLV | 7.3 | -55.0° | 4.2 | 37.2 | -12.0 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 42, GLY, HA1 | A, 39, ILE, O | 3.20Å |
| B, 43, ILE, HA | A, 46, THR, OG1 | 2.74Å |
| A, 42, GLY, HA1 | B, 39, ILE, O | 3.20Å |
| A, 43, ILE, HA | B, 46, THR, OG1 | 2.74Å |
