Low-density lipoprotein receptor-related protein 1B

UniProt data

UniProt name: LRP1B_HUMAN (Q9NZR2)

Gene name: LRP1B; Synonyms=LRPDIT

Organism: Homo sapiens (Human).

Function: Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis.

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 4445-4467, 23 AA, Helical. {ECO:0000255}.

Sequence: 4599 AA

10 20 30 40 50 60 MSEFLLALLT LSGLLPIARV LTVGADRDQQ LCDPGEFLCH DHVTCVSQSW LCDGDPDCPD 70 80 90 100 110 120 DSDESLDTCP EEVEIKCPLN HIACLGTNKC VHLSQLCNGV LDCPDGYDEG VHCQELLSNC 130 140 150 160 170 180 QQLNCQYKCT MVRNSTRCYC EDGFEITEDG RSCKDQDECA VYGTCSQTCR NTHGSYTCSC 190 200 210 220 230 240 VEGYLMQPDN RSCKAKIEPT DRPPILLIAN FETIEVFYLN GSKMATLSSV NGNEIHTLDF 250 260 270 280 290 300 IYNEDMICWI ESRESSNQLK CIQITKAGGL TDEWTINILQ SFHNVQQMAI DWLTRNLYFV 310 320 330 340 350 360 DHVGDRIFVC NSNGSVCVTL IDLELHNPKA IAVDPIAGKL FFTDYGNVAK VERCDMDGMN 370 380 390 400 410 420 RTRIIDSKTE QPAALALDLV NKLVYWVDLY LDYVGVVDYQ GKNRHTVIQG RQVRHLYGIT 430 440 450 460 470 480 VFEDYLYATN SDNYNIVRIN RFNGTDIHSL IKIENAWGIR IYQKRTQPTV RSHACEVDPY 490 500 510 520 530 540 GMPGGCSHIC LLSSSYKTRT CRCRTGFNLG SDGRSCKRPK NELFLFYGKG RPGIVRGMDL 550 560 570 580 590 600 NTKIADEYMI PIENLVNPRA LDFHAETNYI YFADTTSFLI GRQKIDGTER ETILKDDLDN 610 620 630 640 650 660 VEGIAVDWIG NNLYWTNDGH RKTINVARLE KASQSRKTLL EGEMSHPRGI VVDPVNGWMY 670 680 690 700 710 720 WTDWEEDEID DSVGRIEKAW MDGFNRQIFV TSKMLWPNGL TLDFHTNTLY WCDAYYDHIE 730 740 750 760 770 780 KVFLNGTHRK IVYSGRELNH PFGLSHHGNY VFWTDYMNGS IFQLDLITSE VTLLRHERPP 790 800 810 820 830 840 LFGLQIYDPR KQQGDNMCRV NNGGCSTLCL AIPGGRVCAC ADNQLLDENG TTCTFNPGEA 850 860 870 880 890 900 LPHICKAGEF RCKNRHCIQA RWKCDGDDDC LDGSDEDSVN CFNHSCPDDQ FKCQNNRCIP 910 920 930 940 950 960 KRWLCDGAND CGSNEDESNQ TCTARTCQVD QFSCGNGRCI PRAWLCDRED DCGDQTDEMA 970 980 990 1000 1010 1020 SCEFPTCEPL TQFVCKSGRC ISSKWHCDSD DDCGDGSDEV GCVHSCFDNQ FRCSSGRCIP 1030 1040 1050 1060 1070 1080 GHWACDGDND CGDFSDEAQI NCTKEEIHSP AGCNGNEFQC HPDGNCVPDL WRCDGEKDCE 1090 1100 1110 1120 1130 1140 DGSDEKGCNG TIRLCDHKTK FSCWSTGRCI NKAWVCDGDI DCEDQSDEDD CDSFLCGPPK 1150 1160 1170 1180 1190 1200 HPCANDTSVC LQPEKLCNGK KDCPDGSDEG YLCDECSLNN GGCSNHCSVV PGRGIVCSCP 1210 1220 1230 1240 1250 1260 EGLQLNKDNK TCEIVDYCSN HLKCSQVCEQ HKHTVKCSCY EGWKLDVDGE SCTSVDPFEA 1270 1280 1290 1300 1310 1320 FIIFSIRHEI RRIDLHKRDY SLLVPGLRNT IALDFHFNQS LLYWTDVVED RIYRGKLSES 1330 1340 1350 1360 1370 1380 GGVSAIEVVV EHGLATPEGL TVDWIAGNIY WIDSNLDQIE VAKLDGSLRT TLIAGAMEHP 1390 1400 1410 1420 1430 1440 RAIALDPRYG ILFWTDWDAN FPRIESASMS GAGRKTIYKD MKTGAWPNGL TVDHFEKRIV 1450 1460 1470 1480 1490 1500 WTDARSDAIY SALYDGTNMI EIIRGHEYLS HPFAVSLYGS EVYWTDWRTN TLSKANKWTG 1510 1520 1530 1540 1550 1560 QNVSVIQKTS AQPFDLQIYH PSRQPQAPNP CAANDGKGPC SHMCLINHNR SAACACPHLM 1570 1580 1590 1600 1610 1620 KLSSDKKTCY EMKKFLLYAR RSEIRGVDID NPYFNFITAF TVPDIDDVTV IDFDASEERL 1630 1640 1650 1660 1670 1680 YWTDIKTQTI KRAFINGTGL ETVISRDIQS IRGLAVDWVS RNLYWISSEF DETQINVARL 1690 1700 1710 1720 1730 1740 DGSLKTSIIH GIDKPQCLAA HPVRGKLYWT DGNTINMANM DGSNSKILFQ NQKEPVGLSI 1750 1760 1770 1780 1790 1800 DYVENKLYWI SSGNGTINRC NLDGGNLEVI ESMKEELTKA TALTIMDKKL WWADQNLAQL 1810 1820 1830 1840 1850 1860 GTCSKRDGRN PTILRNKTSG VVHMKVYDKE AQQGSNSCQL NNGGCSQLCL PTSETTRTCM 1870 1880 1890 1900 1910 1920 CTVGYYLQKN RMSCQGIESF LMYSVHEGIR GIPLEPSDKM DALMPISGTS FAVGIDFHAE 1930 1940 1950 1960 1970 1980 NDTIYWTDMG FNKISRAKRD QTWKEDIITN GLGRVEGIAV DWIAGNIYWT DHGFNLIEVA 1990 2000 2010 2020 2030 2040 RLNGSFRYVI ISQGLDQPRS IAVHPEKGLL FWTEWGQMPC IGKARLDGSE KVVLVSMGIA 2050 2060 2070 2080 2090 2100 WPNGISIDYE ENKLYWCDAR TDKIERIDLE TGGNREMVLS GSNVDMFSVA VFGAYIYWSD 2110 2120 2130 2140 2150 2160 RAHANGSVRR GHKNDATETI TMRTGLGVNL KEVKIFNRVR EKGTNVCARD NGGCKQLCLY 2170 2180 2190 2200 2210 2220 RGNSRRTCAC AHGYLAEDGV TCLRHEGYLL YSGRTILKSI HLSDETNLNS PIRPYENPRY 2230 2240 2250 2260 2270 2280 FKNVIALAFD YNQRRKGTNR IFYSDAHFGN IQLIKDNWED RQVIVENVGS VEGLAYHRAW 2290 2300 2310 2320 2330 2340 DTLYWTSSTT SSITRHTVDQ TRPGAFDREA VITMSEDDHP HVLALDECQN LMFWTNWNEQ 2350 2360 2370 2380 2390 2400 HPSIMRSTLT GKNAQVVVST DILTPNGLTI DYRAEKLYFS DGSLGKIERC EYDGSQRHVI 2410 2420 2430 2440 2450 2460 VKSGPGTFLS LAVYDNYIFW SDWGRRAILR SNKYTGGDTK ILRSDIPHQP MGIIAVANDT 2470 2480 2490 2500 2510 2520 NSCELSPCAL LNGGCHDLCL LTPNGRVNCS CRGDRILLED NRCVTKNSSC NAYSEFECGN 2530 2540 2550 2560 2570 2580 GECIDYQLTC DGIPHCKDKS DEKLLYCENR SCRRGFKPCY NRRCIPHGKL CDGENDCGDN 2590 2600 2610 2620 2630 2640 SDELDCKVST CATVEFRCAD GTCIPRSARC NQNIDCADAS DEKNCNNTDC THFYKLGVKT 2650 2660 2670 2680 2690 2700 TGFIRCNSTS LCVLPTWICD GSNDCGDYSD ELKCPVQNKH KCEENYFSCP SGRCILNTWI 2710 2720 2730 2740 2750 2760 CDGQKDCEDG RDEFHCDSSC SWNQFACSAQ KCISKHWICD GEDDCGDGLD ESDSICGAIT 2770 2780 2790 2800 2810 2820 CAADMFSCQG SRACVPRHWL CDGERDCPDG SDELSTAGCA PNNTCDENAF MCHNKVCIPK 2830 2840 2850 2860 2870 2880 QFVCDHDDDC GDGSDESPQC GYRQCGTEEF SCADGRCLLN TQWQCDGDFD CPDHSDEAPL 2890 2900 2910 2920 2930 2940 NPKCKSAEQS CNSSFFMCKN GRCIPSGGLC DNKDDCGDGS DERNCHINEC LSKKVSGCSQ 2950 2960 2970 2980 2990 3000 DCQDLPVSYK CKCWPGFQLK DDGKTCVDID ECSSGFPCSQ QCINTYGTYK CLCTDGYEIQ 3010 3020 3030 3040 3050 3060 PDNPNGCKSL SDEEPFLILA DHHEIRKIST DGSNYTLLKQ GLNNVIAIDF DYREEFIYWI 3070 3080 3090 3100 3110 3120 DSSRPNGSRI NRMCLNGSDI KVVHNTAVPN ALAVDWIGKN LYWSDTEKRI IEVSKLNGLY 3130 3140 3150 3160 3170 3180 PTILVSKRLK FPRDLSLDPQ AGYLYWIDCC EYPHIGRVGM DGTNQSVVIE TKISRPMALT 3190 3200 3210 3220 3230 3240 IDYVNRRLYW ADENHIEFSN MDGSHRHKVP NQDIPGVIAL TLFEDYIYWT DGKTKSLSRA 3250 3260 3270 3280 3290 3300 HKTSGADRLS LIYSWHAITD IQVYHSYRQP DVSKHLCMIN NGGCSHLCLL APGKTHTCAC 3310 3320 3330 3340 3350 3360 PTNFYLAADN RTCLSNCTAS QFRCKTDKCI PFWWKCDTVD DCGDGSDEPD DCPEFRCQPG 3370 3380 3390 3400 3410 3420 RFQCGTGLCA LPAFICDGEN DCGDNSDELN CDTHVCLSGQ FKCTKNQKCI PVNLRCNGQD 3430 3440 3450 3460 3470 3480 DCGDEEDERD CPENSCSPDY FQCKTTKHCI SKLWVCDEDP DCADASDEAN CDKKTCGPHE 3490 3500 3510 3520 3530 3540 FQCKNNNCIP DHWRCDSQND CSDNSDEENC KPQTCTLKDF LCANGDCVSS RFWCDGDFDC 3550 3560 3570 3580 3590 3600 ADGSDERNCE TSCSKDQFRC SNGQCIPAKW KCDGHEDCKY GEDEKSCEPA SPTCSSREYI 3610 3620 3630 3640 3650 3660 CASDGCISAS LKCNGEYDCA DGSDEMDCVT ECKEDQFRCK NKAHCIPIRW LCDGIHDCVD 3670 3680 3690 3700 3710 3720 GSDEENCERG GNICRADEFL CNNSLCKLHF WVCDGEDDCG DNSDEAPDMC VKFLCPSTRP 3730 3740 3750 3760 3770 3780 HRCRNNRICL QSEQMCNGID ECGDNSDEDH CGGKLTYKAR PCKKDEFACS NKKCIPMDLQ 3790 3800 3810 3820 3830 3840 CDRLDDCGDG SDEQGCRIAP TEYTCEDNVN PCGDDAYCNQ IKTSVFCRCK PGFQRNMKNR 3850 3860 3870 3880 3890 3900 QCEDLNECLV FGTCSHQCIN VEGSYKCVCD QNFQERNNTC IAEGSEDQVL YIANDTDILG 3910 3920 3930 3940 3950 3960 FIYPFNYSGD HQQISHIEHN SRITGMDVYY QRDMIIWSTQ FNPGGIFYKR IHGREKRQAN 3970 3980 3990 4000 4010 4020 SGLICPEFKR PRDIAVDWVA GNIYWTDHSR MHWFSYYTTH WTSLRYSINV GQLNGPNCTR 4030 4040 4050 4060 4070 4080 LLTNMAGEPY AIAVNPKRGM MYWTVVGDHS HIEEAAMDGT LRRILVQKNL QRPTGLAVDY 4090 4100 4110 4120 4130 4140 FSERIYWADF ELSIIGSVLY DGSNSVVSVS SKQGLLHPHR IDIFEDYIYG AGPKNGVFRV 4150 4160 4170 4180 4190 4200 QKFGHGSVEY LALNIDKTKG VLISHRYKQL DLPNPCLDLA CEFLCLLNPS GATCVCPEGK 4210 4220 4230 4240 4250 4260 YLINGTCNDD SLLDDSCKLT CENGGRCILN EKGDLRCHCW PSYSGERCEV NHCSNYCQNG 4270 4280 4290 4300 4310 4320 GTCVPSVLGR PTCSCALGFT GPNCGKTVCE DFCQNGGTCI VTAGNQPYCH CQPEYTGDRC 4330 4340 4350 4360 4370 4380 QYYVCHHYCV NSESCTIGDD GSVECVCPTR YEGPKCEVDK CVRCHGGHCI INKDSEDIFC 4390 4400 4410 4420 4430 4440 NCTNGKIASS CQLCDGYCYN GGTCQLDPET NVPVCLCSTN WSGTQCERPA PKSSKSDHIS 4450 4460 4470 4480 4490 4500 TRSIAIIVPL VLLVTLITTL VIGLVLCKRK RRTKTIRRQP IINGGINVEI GNPSYNMYEV 4510 4520 4530 4540 4550 4560 DHDHNDGGLL DPGFMIDPTK ARYIGGGPSA FKLPHTAPPI YLNSDLKGPL TAGPTNYSNP 4570 4580 4590 VYAKLYMDGQ NCRNSLGSVD ERKELLPKKI EIGIRETVA

CATM prediction

The sequence of LRP1B_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          4450      4460      4
   +    |    +    |    +    |
(Å) (°) (Å) (°)  
RSIAIIVALVLLVTLITTLVIGLVLCKRK 7.3 -47.1° 2.2 45.1 -8.9
RSIAIIVPLVLLVTLITTLVIGLVLCKRK          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 4460, LEU, HA A, 4459, THR, O 3.42Å
B, 4463, GLY, HA1 A, 4460, LEU, O 3.24Å
A, 4460, LEU, HA B, 4459, THR, O 3.42Å
A, 4463, GLY, HA1 B, 4460, LEU, O 3.24Å