Programmed cell death 1 ligand 1

UniProt data

UniProt name: PD1L1_HUMAN (Q9NZQ7)

Gene name: CD274; Synonyms=B7H1, PDCD1L1, PDCD1LG1, PDL1

Organism: Homo sapiens (Human).

Function: Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production. {ECO:0000269|PubMed:10581077, ECO:0000269|PubMed:11015443}.

Subcellular location: Isoform 2: Endomembrane system {ECO:0000269|PubMed:15780196}; Single-pass type I membrane protein {ECO:0000255}.

Transmembrane domains:

  1. 239-259, 21 AA, Helical. {ECO:0000255}.

Sequence: 290 AA

10 20 30 40 50 60 MRIFAVFIFM TYWHLLNAFT VTVPKDLYVV EYGSNMTIEC KFPVEKQLDL AALIVYWEME 70 80 90 100 110 120 DKNIIQFVHG EEDLKVQHSS YRQRARLLKD QLSLGNAALQ ITDVKLQDAG VYRCMISYGG 130 140 150 160 170 180 ADYKRITVKV NAPYNKINQR ILVVDPVTSE HELTCQAEGY PKAEVIWTSS DHQVLSGKTT 190 200 210 220 230 240 TTNSKREEKL FNVTSTLRIN TTTNEIFYCT FRRLDPEENH TAELVIPELP LAHPPNERTH 250 260 270 280 LVILGAILLC LGVALTFIFR LRKGRMMDVK KCGIQDTNSK KQSDTHLEET

CATM prediction

The sequence of PD1L1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      240       250       260
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 NERTHLVILGAILLCLGVALTFIFRLR 7.4 -40.8° 3.5 37.9 -10.8

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 249, LEU, HA A, 248, LEU, O 3.40Å
B, 252, GLY, HA1 A, 249, LEU, O 3.43Å
B, 253, VAL, HA A, 256, THR, OG1 2.64Å
A, 249, LEU, HA B, 248, LEU, O 3.40Å
A, 252, GLY, HA1 B, 249, LEU, O 3.43Å
A, 253, VAL, HA B, 256, THR, OG1 2.64Å