CDGSH iron-sulfur domain-containing protein 1

UniProt data

UniProt name: CISD1_HUMAN (Q9NZ45)

Gene name: CISD1; Synonyms=C10orf70, ZCD1; ORFNames=MDS029

Organism: Homo sapiens (Human).

Function: Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation (By similarity). May be involved in Fe-S cluster shuttling and/or in redox reactions. {ECO:0000250, ECO:0000269|PubMed:17584744, ECO:0000269|PubMed:17766440}.

Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:17376863, ECO:0000269|PubMed:17766439, ECO:0000269|PubMed:17905743, ECO:0000269|PubMed:18047834}; Single- pass type III membrane protein {ECO:0000269|PubMed:17376863, ECO:0000269|PubMed:17766439, ECO:0000269|PubMed:17905743, ECO:0000269|PubMed:18047834}.

Transmembrane domains:

  1. 14-31, 18 AA, Helical; Signal-anchor for type III membrane protein. {ECO:0000255}.

Sequence: 108 AA

10 20 30 40 50 60 MSLTSSSSVR VEWIAAVTIA AGTAAIGYLA YKRFYVKDHR NKAMINLHIQ KDNPKIVHAF 70 80 90 100 DMEDLGDKAV YCRCWRSKKF PFCDGAHTKH NEETGDNVGP LIIKKKET

CATM prediction

The sequence of CISD1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
           20        30   
    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 VEWIAAVTIAAGTAAIGYLAYKRF 7.0 -53.4° 3.2 33.7 -1.5

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 24, ALA, HA A, 23, THR, O 3.19Å
B, 27, GLY, HA1 A, 24, ALA, O 3.10Å
A, 24, ALA, HA B, 23, THR, O 3.19Å
A, 27, GLY, HA1 B, 24, ALA, O 3.10Å