Sialic acid-binding Ig-like lectin 8

UniProt data

UniProt name: SIGL8_HUMAN (Q9NYZ4)

Gene name: SIGLEC8; Synonyms=SAF2

Organism: Homo sapiens (Human).

Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 364-384, 21 AA, Helical. {ECO:0000255}.

Sequence: 499 AA

10 20 30 40 50 60 MLLLLLLLPL LWGTKGMEGD RQYGDGYLLQ VQELVTVQEG LCVHVPCSFS YPQDGWTDSD 70 80 90 100 110 120 PVHGYWFRAG DRPYQDAPVA TNNPDREVQA ETQGRFQLLG DIWSNDCSLS IRDARKRDKG 130 140 150 160 170 180 SYFFRLERGS MKWSYKSQLN YKTKQLSVFV TALTHRPDIL ILGTLESGHS RNLTCSVPWA 190 200 210 220 230 240 CKQGTPPMIS WIGASVSSPG PTTARSSVLT LTPKPQDHGT SLTCQVTLPG TGVTTTSTVR 250 260 270 280 290 300 LDVSYPPWNL TMTVFQGDAT ASTALGNGSS LSVLEGQSLR LVCAVNSNPP ARLSWTRGSL 310 320 330 340 350 360 TLCPSRSSNP GLLELPRVHV RDEGEFTCRA QNAQGSQHIS LSLSLQNEGT GTSRPVSQVT 370 380 390 400 410 420 LAAVGGAGAT ALAFLSFCII FIIVRSCRKK SARPAAGVGD TGMEDAKAIR GSASQGPLTE 430 440 450 460 470 480 SWKDGNPLKK PPPAVAPSSG EEGELHYATL SFHKVKPQDP QGQEATDSEY SEIKIHKRET 490 AETQACLRNH NPSSKEVRG

CATM prediction

The sequence of SIGL8_HUMAN returned 4 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
           370       380     
    +    |    +    |    +  		 (Å) (°) (Å) (°)  
Model 1 LAAVGGAGATALAFLSFCIIFIIVRSC 7.3 -43.0° 3.0 35.0 -18.1
Model 2 LAAVGGAGATALAFLSFCIIFIIVRSC 7.2 -37.0° 0.0 37.0 -13.4
Model 3 LAAVGGAGATALAFLSFCIIFIIVRSC 6.7 -40.0° 4.0 38.0 -4.0
Model 4 LAAVGGAGATALAFLSFCIIFIIVRSC 7.1 -55.0° 4.2 38.0 -2.0

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 367, ALA, HA A, 370, THR, OG1 2.66Å
A, 367, ALA, HA B, 370, THR, OG1 2.66Å