BET1-like protein

UniProt data

UniProt name: BET1L_HUMAN (Q9NYM9)

Gene name: BET1L {ECO:0000312|HGNC:HGNC:19348}

Organism: Homo sapiens (Human).

Function: Vesicle SNARE required for targeting and fusion of retrograde transport vesicles with the Golgi complex. Required for the integrity of the Golgi complex (By similarity). {ECO:0000250|UniProtKB:O35152}.

Subcellular location: Golgi apparatus membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}. Note=Present throughout the Golgi apparatus, with increasing concentration from cis-Golgi to the trans-Golgi face of the stacks. {ECO:0000250}.

Transmembrane domains:

  1. 87-107, 21 AA, Helical; Anchor for type IV membrane protein. {ECO:0000255}.

Sequence: 111 AA

10 20 30 40 50 60 MADWARAQSP GAVEEILDRE NKRMADSLAS KVTRLKSLAL DIDRDAEDQN RYLDGMDSDF 70 80 90 100 110 TSMTSLLTGS VKRFSTMARS GQDNRKLLCG MAVGLIVAFF ILSYFLSRAR T

CATM prediction

The sequence of BET1L_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        90        100       1
 +    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 NRKLLCGMAVGLIVAFFILSYFLSRAR 6.8 -28.2° 2.4 50.2 -41.1
Model 2 NRKLLCGMAVGLIVAFFILSYFLSRAR 6.4 -46.9° 3.9 53.1 -26.5
Model 3 NRKLLCGMAVGLIVAFFILSYFLSRAR 6.8 -41.7° 2.8 50.1 -20.9

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 90, GLY, HA1 A, 87, LEU, O 2.96Å
B, 91, MET, HA A, 90, GLY, O 3.03Å
A, 90, GLY, HA1 B, 87, LEU, O 2.96Å
A, 91, MET, HA B, 90, GLY, O 3.03Å