Peptidyl-prolyl cis-trans isomerase FKBP11

UniProt data

UniProt name: FKB11_HUMAN (Q9NYL4)

Gene name: FKBP11; Synonyms=FKBP19; ORFNames=UNQ336/PRO535

Organism: Homo sapiens (Human).

Function: PPIases accelerate the folding of proteins during protein synthesis.

Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 156-176, 21 AA, Helical. {ECO:0000255}.

Sequence: 201 AA

10 20 30 40 50 60 MTLRPSLLPL HLLLLLLLSA AVCRAEAGLE TESPVRTLQV ETLVEPPEPC AEPAAFGDTL 70 80 90 100 110 120 HIHYTGSLVD GRIIDTSLTR DPLVIELGQK QVIPGLEQSL LDMCVGEKRR AIIPSHLAYG 130 140 150 160 170 180 KRGFPPSVPA DAVVQYDVEL IALIRANYWL KLVKGILPLV GMAMVPALLG LIGYHLYRKA 190 200 NRPKVSKKKL KEEKRNKSKK K

CATM prediction

The sequence of FKB11_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         160       170       
  +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 VKGILALVGMAMVAALLGLIGYHLYRK 6.7 -50.9° 4.3 39.9 -39.5
Prolines* VKGILPLVGMAMVPALLGLIGYHLYRK          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 167, ALA, HA A, 166, ALA, O 2.75Å
B, 170, GLY, HA1 A, 167, ALA, O 3.07Å
B, 174, TYR, HH A, 175, HSE, ND1 2.56Å
A, 167, ALA, HA B, 166, ALA, O 2.75Å
A, 170, GLY, HA1 B, 167, ALA, O 3.07Å
A, 174, TYR, HH B, 175, HSE, ND1 2.56Å