Delta-like protein 3

UniProt data

UniProt name: DLL3_HUMAN (Q9NYJ7)

Gene name: DLL3

Organism: Homo sapiens (Human).

Function: Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity). {ECO:0000250}.

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 493-513, 21 AA, Helical. {ECO:0000255}.

Sequence: 618 AA

10 20 30 40 50 60 MVSPRMSGLL SQTVILALIF LPQTRPAGVF ELQIHSFGPG PGPGAPRSPC SARLPCRLFF 70 80 90 100 110 120 RVCLKPGLSE EAAESPCALG AALSARGPVY TEQPGAPAPD LPLPDGLLQV PFRDAWPGTF 130 140 150 160 170 180 SFIIETWREE LGDQIGGPAW SLLARVAGRR RLAAGGPWAR DIQRAGAWEL RFSYRARCEP 190 200 210 220 230 240 PAVGTACTRL CRPRSAPSRC GPGLRPCAPL EDECEAPLVC RAGCSPEHGF CEQPGECRCL 250 260 270 280 290 300 EGWTGPLCTV PVSTSSCLSP RGPSSATTGC LVPGPGPCDG NPCANGGSCS ETPRSFECTC 310 320 330 340 350 360 PRGFYGLRCE VSGVTCADGP CFNGGLCVGG ADPDSAYICH CPPGFQGSNC EKRVDRCSLQ 370 380 390 400 410 420 PCRNGGLCLD LGHALRCRCR AGFAGPRCEH DLDDCAGRAC ANGGTCVEGG GAHRCSCALG 430 440 450 460 470 480 FGGRDCRERA DPCAARPCAH GGRCYAHFSG LVCACAPGYM GARCEFPVHP DGASALPAAP 490 500 510 520 530 540 PGLRPGDPQR YLLPPALGLL VAAGVAGAAL LLVHVRRRGH SQDAGSRLLA GTPEPSVHAL 550 560 570 580 590 600 PDALNNLRTQ EGSGDGPSSS VDWNRPEDVD PQGIYVISAP SIYAREVATP LFPPLHTGRA 610 GQRQHLLFPY PSSILSVK

CATM prediction

The sequence of DLL3_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  490       500       510    
|    +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 RYLLAAALGLLVAAGVAGAALLLVHVR 6.8 -46.0° 2.7 47.1 -27.3
Model 2 RYLLAAALGLLVAAGVAGAALLLVHVR 6.6 -49.3° 3.9 37.9 -15.8
Model 3 RYLLAAALGLLVAAGVAGAALLLVHVR 7.3 -29.0° 2.5 37.0 -9.5
Prolines* RYLLPPALGLLVAAGVAGAALLLVHVR          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 495, ALA, HA A, 494, ALA, O 2.67Å
B, 498, GLY, HA1 A, 495, ALA, O 2.57Å
B, 499, LEU, HA A, 498, GLY, O 3.12Å
A, 495, ALA, HA B, 494, ALA, O 2.67Å
A, 498, GLY, HA1 B, 495, ALA, O 2.57Å
A, 499, LEU, HA B, 498, GLY, O 3.12Å