Voltage-dependent calcium channel subunit alpha-2/delta-2

UniProt data

UniProt name: CA2D2_HUMAN (Q9NY47)

Gene name: CACNA2D2; Synonyms=KIAA0558

Organism: Homo sapiens (Human).

Function: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis. {ECO:0000269|PubMed:12555074, ECO:0000269|PubMed:15111129}.

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Colocalizes with CACNA1A in lipid raft fractions. {ECO:0000250}.

Transmembrane domains:

  1. 1114-1134, 21 AA, Helical. {ECO:0000255}.

Sequence: 1150 AA

10 20 30 40 50 60 MAVPARTCGA SRPGPARTAR PWPGCGPHPG PGTRRPTSGP PRPLWLLLPL LPLLAAPGAS 70 80 90 100 110 120 AYSFPQQHTM QHWARRLEQE VDGVMRIFGG VQQLREIYKD NRNLFEVQEN EPQKLVEKVA 130 140 150 160 170 180 GDIESLLDRK VQALKRLADA AENFQKAHRW QDNIKEEDIV YYDAKADAEL DDPESEDVER 190 200 210 220 230 240 GSKASTLRLD FIEDPNFKNK VNYSYAAVQI PTDIYKGSTV ILNELNWTEA LENVFMENRR 250 260 270 280 290 300 QDPTLLWQVF GSATGVTRYY PATPWRAPKK IDLYDVRRRP WYIQGASSPK DMVIIVDVSG 310 320 330 340 350 360 SVSGLTLKLM KTSVCEMLDT LSDDDYVNVA SFNEKAQPVS CFTHLVQANV RNKKVFKEAV 370 380 390 400 410 420 QGMVAKGTTG YKAGFEYAFD QLQNSNITRA NCNKMIMMFT DGGEDRVQDV FEKYNWPNRT 430 440 450 460 470 480 VRVFTFSVGQ HNYDVTPLQW MACANKGYYF EIPSIGAIRI NTQEYLDVLG RPMVLAGKEA 490 500 510 520 530 540 KQVQWTNVYE DALGLGLVVT GTLPVFNLTQ DGPGEKKNQL ILGVMGIDVA LNDIKRLTPN 550 560 570 580 590 600 YTLGANGYVF AIDLNGYVLL HPNLKPQTTN FREPVTLDFL DAELEDENKE EIRRSMIDGN 610 620 630 640 650 660 KGHKQIRTLV KSLDERYIDE VTRNYTWVPI RSTNYSLGLV LPPYSTFYLQ ANLSDQILQV 670 680 690 700 710 720 KLPISKLKDF EFLLPSSFES EGHVFIAPRE YCKDLNASDN NTEFLKNFIE LMEKVTPDSK 730 740 750 760 770 780 QCNNFLLHNL ILDTGITQQL VERVWRDQDL NTYSLLAVFA ATDGGITRVF PNKAAEDWTE 790 800 810 820 830 840 NPEPFNASFY RRSLDNHGYV FKPPHQDALL RPLELENDTV GILVSTAVEL SLGRRTLRPA 850 860 870 880 890 900 VVGVKLDLEA WAEKFKVLAS NRTHQDQPQK CGPNSHCEMD CEVNNEDLLC VLIDDGGFLV 910 920 930 940 950 960 LSNQNHQWDQ VGRFFSEVDA NLMLALYNNS FYTRKESYDY QAACAPQPPG NLGAAPRGVF 970 980 990 1000 1010 1020 VPTVADFLNL AWWTSAAAWS LFQQLLYGLI YHSWFQADPA EAEGSPETRE SSCVMKQTQY 1030 1040 1050 1060 1070 1080 YFGSVNASYN AIIDCGNCSR LFHAQRLTNT NLLFVVAEKP LCSQCEAGRL LQKETHSDGP 1090 1100 1110 1120 1130 1140 EQCELVQRPR YRRGPHICFD YNATEDTSDC GRGASFPPSL GVLVSLQLLL LLGLPPRPQP QVLVHASRRL

CATM prediction

The sequence of CA2D2_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
           1120      1130    
    +    |    +    |    +  		 (Å) (°) (Å) (°)  
Model 1 GRGASFAASLGVLVSLQLLLLLGLAAR 7.0 -45.9° 4.7 37.8 -16.5
Model 2 GRGASFAASLGVLVSLQLLLLLGLAAR 7.3 -30.0° 3.0 38.0 -10.3
Prolines* GRGASFPPSLGVLVSLQLLLLLGLPPR          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 1118, ALA, HA A, 1117, ALA, O 2.82Å
B, 1121, GLY, HA1 A, 1118, ALA, O 3.09Å
B, 1122, VAL, HA A, 1125, SER, OG 3.48Å
B, 1125, SER, HG1 A, 1125, SER, OG 1.93Å
A, 1118, ALA, HA B, 1117, ALA, O 2.82Å
A, 1121, GLY, HA1 B, 1118, ALA, O 3.09Å