Probable polypeptide N-acetylgalactosaminyltransferase 8

UniProt data

UniProt name: GALT8_HUMAN (Q9NY28)

Gene name: GALNT8

Organism: Homo sapiens (Human).

Function: Probably catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. {ECO:0000250}.

Subcellular location: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Transmembrane domains:

  1. 7-29, 23 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 637 AA

10 20 30 40 50 60 MMFWRKLPKA LFIGLTLAIA VNLLLVFSSK GTLQNLFTGG LHRELPLHLN KRYGAVIKRL 70 80 90 100 110 120 SHLEVELQDL KESMKLALRQ QENVNSTLKR AKDEVRPLLK AMETKVNETK KHKTQMKLFP 130 140 150 160 170 180 HSQLFRQWGE DLSEAQQKAA QDLFRKFGYN AYLSNQLPLN RTIPDTRDYR CLRKTYPSQL 190 200 210 220 230 240 PSLSVILIFV NEALSIIQRA ITSIINRTPS RLLKEIILVD DFSSNGELKV HLDEKIKLYN 250 260 270 280 290 300 QKYPGLLKII RHPERKGLAQ ARNTGWEAAT ADVVAILDAH IEVNVGWAEP ILARIQEDRT 310 320 330 340 350 360 VIVSPVFDNI RFDTFKLDKY ELAVDGFNWE LWCRYDALPQ AWIDLHDVTA PVKSPSIMGI 370 380 390 400 410 420 LAANRHFLGE IGSLDGGMLI YGGENVELSL RVWQCGGKVE ILPCSRIAHL ERHHKPYALD 430 440 450 460 470 480 LTAALKRNAL RVAEIWMDEH KHMVYLAWNI PLQNSGIDFG DVSSRMALRE KLKCKTFDWY 490 500 510 520 530 540 LKNVYPLLKP LHTIVGYGRM KNLLDENVCL DQGPVPGNTP IMYYCHEFSS QNVYYHLTGE 550 560 570 580 590 600 LYVGQLIAEA SASDRCLTDP GKAEKPTLEP CSKAAKNRLH IYWDFKPGGA VINRDTKRCL 610 620 630 EMKKDLLGSH VLVLQTCSTQ VWEIQHTVRD WGQTNSQ

CATM prediction

The sequence of GALT8_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        10        20        30 
 +    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 WRKLAKALFIGLTLAIAVNLLLVFSSKGT 7.2 -42.0° 2.9 49.7 -25.5
Prolines* WRKLPKALFIGLTLAIAVNLLLVFSSKGT          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 11, LEU, HA A, 10, ALA, O 3.02Å
B, 14, GLY, HA1 A, 11, LEU, O 3.21Å
A, 11, LEU, HA B, 10, ALA, O 3.02Å
A, 14, GLY, HA1 B, 11, LEU, O 3.21Å