C-type lectin domain family 5 member A

UniProt data

UniProt name: CLC5A_HUMAN (Q9NY25)

Gene name: CLEC5A; Synonyms=CLECSF5, MDL1

Organism: Homo sapiens (Human).

Function: (Microbial infection) May act as a receptor for dengue virus on macrophages. The binding of dengue virus to CLEC5A triggers signaling through the phosphylation of TYROBP, this interaction does not result in viral entry, but stimulates proinflammatory cytokine release. {ECO:0000269|PubMed:18496526, ECO:0000269|PubMed:21566123}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:21566123}; Single-pass type II membrane protein {ECO:0000269|PubMed:21566123}.

Transmembrane domains:

  1. 5-27, 23 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 188 AA

10 20 30 40 50 60 MNWHMIISGL IVVVLKVVGM TLFLLYFPQI FNKSNDGFTT TRSYGTVSQI FGSSSPSPNG 70 80 90 100 110 120 FITTRSYGTV CPKDWEFYQA RCFFLSTSES SWNESRDFCK GKGSTLAIVN TPEKLKFLQD 130 140 150 160 170 180 ITDAEKYFIG LIYHREEKRW RWINNSVFNG NVTNQNQNFN CATIGLTKTF DAASCDISYR RICEKNAK

CATM prediction

The sequence of CLC5A_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          10        20        3
   +    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 NWHMIISGLIVVVLKVVGMTLFLLYFAQI 7.0 -55.1° 1.5 45.1 -19.5
Model 2 NWHMIISGLIVVVLKVVGMTLFLLYFAQI 7.4 -51.0° 3.3 47.9 -17.7
Prolines* NWHMIISGLIVVVLKVVGMTLFLLYFPQI          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 16, LYS, HA A, 15, LEU, O 3.47Å
B, 19, GLY, HA1 A, 16, LYS, O 2.93Å
B, 20, MET, HA A, 19, GLY, O 3.46Å
A, 16, LYS, HA B, 15, LEU, O 3.47Å
A, 19, GLY, HA1 B, 16, LYS, O 2.93Å
A, 20, MET, HA B, 19, GLY, O 3.46Å