Stabilin-1

UniProt data

UniProt name: STAB1_HUMAN (Q9NY15)

Gene name: STAB1; Synonyms=FEEL1, KIAA0246

Organism: Homo sapiens (Human).

Function: Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial tube formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis. Involved in the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system. {ECO:0000269|PubMed:12077138, ECO:0000269|PubMed:16357325}.

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 2479-2499, 21 AA, Helical. {ECO:0000255}.

Sequence: 2570 AA

10 20 30 40 50 60 MAGPRGLLPL CLLAFCLAGF SFVRGQVLFK GCDVKTTFVT HVPCTSCAAI KKQTCPSGWL 70 80 90 100 110 120 RELPDQITQD CRYEVQLGGS MVSMSGCRRK CRKQVVQKAC CPGYWGSRCH ECPGGAETPC 130 140 150 160 170 180 NGHGTCLDGM DRNGTCVCQE NFRGSACQEC QDPNRFGPDC QSVCSCVHGV CNHGPRGDGS 190 200 210 220 230 240 CLCFAGYTGP HCDQELPVCQ ELRCPQNTQC SAEAPSCRCL PGYTQQGSEC RAPNPCWPSP 250 260 270 280 290 300 CSLLAQCSVS PKGQAQCHCP ENYHGDGMVC LPKDPCTDNL GGCPSNSTLC VYQKPGQAFC 310 320 330 340 350 360 TCRPGLVSIN SNASAGCFAF CSPFSCDRSA TCQVTADGKT SCVCRESEVG DGRACYGHLL 370 380 390 400 410 420 HEVQKATQTG RVFLQLRVAV AMMDQGCREI LTTAGPFTVL VPSVSSFSSR TMNASLAQQL 430 440 450 460 470 480 CRQHIIAGQH ILEDTRTQQT RRWWTLAGQE ITVTFNQFTK YSYKYKDQPQ QTFNIYKANN 490 500 510 520 530 540 IAANGVFHVV TGLRWQAPSG TPGDPKRTIG QILASTEAFS RFETILENCG LPSILDGPGP 550 560 570 580 590 600 FTVFAPSNEA VDSLRDGRLI YLFTAGLSKL QELVRYHIYN HGQLTVEKLI SKGRILTMAN 610 620 630 640 650 660 QVLAVNISEE GRILLGPEGV PLQRVDVMAA NGVIHMLDGI LLPPTILPIL PKHCSEEQHK 670 680 690 700 710 720 IVAGSCVDCQ ALNTSTCPPN SVKLDIFPKE CVYIHDPTGL NVLKKGCASY CNQTIMEQGC 730 740 750 760 770 780 CKGFFGPDCT QCPGGFSNPC YGKGNCSDGI QGNGACLCFP DYKGIACHIC SNPNKHGEQC 790 800 810 820 830 840 QEDCGCVHGL CDNRPGSGGV CQQGTCAPGF SGRFCNESMG DCGPTGLAQH CHLHARCVSQ 850 860 870 880 890 900 EGVARCRCLD GFEGDGFSCT PSNPCSHPDR GGCSENAECV PGSLGTHHCT CHKGWSGDGR 910 920 930 940 950 960 VCVAIDECEL DMRGGCHTDA LCSYVGPGQS RCTCKLGFAG DGYQCSPIDP CRAGNGGCHG 970 980 990 1000 1010 1020 LATCRAVGGG QRVCTCPPGF GGDGFSCYGD IFRELEANAH FSIFYQWLKS AGITLPADRR 1030 1040 1050 1060 1070 1080 VTALVPSEAA VRQLSPEDRA FWLQPRTLPN LVRAHFLQGA LFEEELARLG GQEVATLNPT 1090 1100 1110 1120 1130 1140 TRWEIRNISG RVWVQNASVD VADLLATNGV LHILSQVLLP PRGDVPGGQG LLQQLDLVPA 1150 1160 1170 1180 1190 1200 FSLFRELLQH HGLVPQIEAA TAYTIFVPTN RSLEAQGNSS HLDADTVRHH VVLGEALSME 1210 1220 1230 1240 1250 1260 TLRKGGHRNS LLGPAHWIVF YNHSGQPEVN HVPLEGPMLE APGRSLIGLS GVLTVGSSRC 1270 1280 1290 1300 1310 1320 LHSHAEALRE KCVNCTRRFR CTQGFQLQDT PRKSCVYRSG FSFSRGCSYT CAKKIQVPDC 1330 1340 1350 1360 1370 1380 CPGFFGTLCE PCPGGLGGVC SGHGQCQDRF LGSGECHCHE GFHGTACEVC ELGRYGPNCT 1390 1400 1410 1420 1430 1440 GVCDCAHGLC QEGLQGDGSC VCNVGWQGLR CDQKITSPQC PRKCDPNANC VQDSAGASTC 1450 1460 1470 1480 1490 1500 ACAAGYSGNG IFCSEVDPCA HGHGGCSPHA NCTKVAPGQR TCTCQDGYMG DGELCQEINS 1510 1520 1530 1540 1550 1560 CLIHHGGCHI HAECIPTGPQ QVSCSCREGY SGDGIRTCEL LDPCSKNNGG CSPYATCKST 1570 1580 1590 1600 1610 1620 GDGQRTCTCD TAHTVGDGLT CRARVGLELL RDKHASFFSL RLLEYKELKG DGPFTIFVPH 1630 1640 1650 1660 1670 1680 ADLMSNLSQD ELARIRAHRQ LVFRYHVVGC RRLRSEDLLE QGYATALSGH PLRFSEREGS 1690 1700 1710 1720 1730 1740 IYLNDFARVV SSDHEAVNGI LHFIDRVLLP PEALHWEPDD APIPRRNVTA AAQGFGYKIF 1750 1760 1770 1780 1790 1800 SGLLKVAGLL PLLREASHRP FTMLWPTDAA FRALPPDRQA WLYHEDHRDK LAAILRGHMI 1810 1820 1830 1840 1850 1860 RNVEALASDL PNLGPLRTMH GTPISFSCSR TRAGELMVGE DDARIVQRHL PFEGGLAYGI 1870 1880 1890 1900 1910 1920 DQLLEPPGLG ARCDHFETRP LRLNTCSICG LEPPCPEGSQ EQGSPEACWR FYPKFWTSPP 1930 1940 1950 1960 1970 1980 LHSLGLRSVW VHPSLWGRPQ GLGRGCHRNC VTTTWKPSCC PGHYGSECQA CPGGPSSPCS 1990 2000 2010 2020 2030 2040 DRGVCMDGMS GSGQCLCRSG FAGTACELCA PGAFGPHCQA CRCTVHGRCD EGLGGSGSCF 2050 2060 2070 2080 2090 2100 CDEGWTGPRC EVQLELQPVC TPPCAPEAVC RAGNSCECSL GYEGDGRVCT VADLCQDGHG 2110 2120 2130 2140 2150 2160 GCSEHANCSQ VGTMVTCTCL PDYEGDGWSC RARNPCTDGH RGGCSEHANC LSTGLNTRRC 2170 2180 2190 2200 2210 2220 ECHAGYVGDG LQCLEESEPP VDRCLGQPPP CHSDAMCTDL HFQEKRAGVF HLQATSGPYG 2230 2240 2250 2260 2270 2280 LNFSEAEAAC EAQGAVLASF PQLSAAQQLG FHLCLMGWLA NGSTAHPVVF PVADCGNGRV 2290 2300 2310 2320 2330 2340 GIVSLGARKN LSERWDAYCF RVQDVACRCR NGFVGDGIST CNGKLLDVLA ATANFSTFYG 2350 2360 2370 2380 2390 2400 MLLGYANATQ RGLDFLDFLD DELTYKTLFV PVNEGFVDNM TLSGPDLELH ASNATLLSAN 2410 2420 2430 2440 2450 2460 ASQGKLLPAH SGLSLIISDA GPDNSSWAPV APGTVVVSRI IVWDIMAFNG IIHALASPLL 2470 2480 2490 2500 2510 2520 APPQPQAVLA PEAPPVAAGV GAVLAAGALL GLVAGALYLR ARGKPMGFGF SAFQAEDDAD 2530 2540 2550 2560 DDFSPWQEGT NPTLVSVPNP VFGSDTFCEP FDDSLLEEDF PDTQRILTVK

CATM prediction

The sequence of STAB1_HUMAN returned 7 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      2480      2490      250
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 VAAGVGAVLAAGALLGLVAGALYLRAR 6.5 -40.4° 4.0 62.9 -39.2
Model 2 VAAGVGAVLAAGALLGLVAGALYLRAR 6.5 -40.9° 0.1 44.8 -30.3
Model 3 VAAGVGAVLAAGALLGLVAGALYLRAR 7.1 -43.2° -0.0 34.6 -19.1
Model 4 VAAGVGAVLAAGALLGLVAGALYLRAR 6.5 -53.8° 3.6 35.0 -13.5
Model 5 VAAGVGAVLAAGALLGLVAGALYLRAR 7.0 +54.0° 3.3 79.9 -9.9
Model 6 VAAGVGAVLAAGALLGLVAGALYLRAR 6.8 -55.4° 1.5 45.0 -8.3
Model 7 VAAGVGAVLAAGALLGLVAGALYLRAR 7.0 -41.7° 1.9 33.0 -1.1

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 2484, LEU, HA A, 2483, VAL, O 3.38Å
B, 2487, GLY, HA1 A, 2484, LEU, O 2.98Å
B, 2488, ALA, HA A, 2487, GLY, O 2.51Å
B, 2491, GLY, HA1 A, 2488, ALA, O 3.17Å
A, 2484, LEU, HA B, 2483, VAL, O 3.38Å
A, 2487, GLY, HA1 B, 2484, LEU, O 2.98Å
A, 2488, ALA, HA B, 2487, GLY, O 2.51Å
A, 2491, GLY, HA1 B, 2488, ALA, O 3.17Å