Glutaminyl-peptide cyclotransferase-like protein

UniProt data

UniProt name: QPCTL_HUMAN (Q9NXS2)

Gene name: QPCTL

Organism: Homo sapiens (Human).

Function: Responsible for the biosynthesis of pyroglutamyl peptides. {ECO:0000269|PubMed:18486145, ECO:0000269|PubMed:21288892}.

Subcellular location: Golgi apparatus membrane {ECO:0000269|PubMed:18486145}; Single-pass type I membrane protein {ECO:0000269|PubMed:18486145}.

Transmembrane domains:

  1. 35-55, 21 AA, Helical. {ECO:0000255}.

Sequence: 382 AA

10 20 30 40 50 60 MRSGGRGRPR LRLGERGLME PLLPPKRRLL PRVRLLPLLL ALAVGSAFYT IWSGWHRRTE 70 80 90 100 110 120 ELPLGRELRV PLIGSLPEAR LRRVVGQLDP QRLWSTYLRP LLVVRTPGSP GNLQVRKFLE 130 140 150 160 170 180 ATLRSLTAGW HVELDPFTAS TPLGPVDFGN VVATLDPRAA RHLTLACHYD SKLFPPGSTP 190 200 210 220 230 240 FVGATDSAVP CALLLELAQA LDLELSRAKK QAAPVTLQLL FLDGEEALKE WGPKDSLYGS 250 260 270 280 290 300 RHLAQLMESI PHSPGPTRIQ AIELFMLLDL LGAPNPTFYS HFPRTVRWFH RLRSIEKRLH 310 320 330 340 350 360 RLNLLQSHPQ EVMYFQPGEP FGSVEDDHIP FLRRGVPVLH LISTPFPAVW HTPADTEVNL 370 380 HPPTVHNLCR ILAVFLAEYL GL

CATM prediction

The sequence of QPCTL_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          40        50       
   +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 RVRLLALLLALAVGSAFYTIWSGWHRR 7.3 -53.9° 2.8 51.0 -7.1
Prolines* RVRLLPLLLALAVGSAFYTIWSGWHRR          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 42, LEU, HA A, 41, ALA, O 3.31Å
B, 45, GLY, HA1 A, 42, LEU, O 3.26Å
B, 50, THR, HA A, 49, TYR, OH 3.24Å
B, 50, THR, HG1 A, 49, TYR, OH 2.20Å
A, 42, LEU, HA B, 41, ALA, O 3.31Å
A, 45, GLY, HA1 B, 42, LEU, O 3.26Å
A, 50, THR, HG1 B, 49, TYR, OH 2.49Å