Sphingomyelin phosphodiesterase 4

UniProt data

UniProt name: NSMA3_HUMAN (Q9NXE4)

Gene name: SMPD4; Synonyms=KIAA1418

Organism: Homo sapiens (Human).

Function: Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. {ECO:0000269|PubMed:16517606}.

Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16517606}; Single-pass membrane protein {ECO:0000269|PubMed:16517606}. Golgi apparatus membrane {ECO:0000269|PubMed:16517606}; Single-pass membrane protein {ECO:0000269|PubMed:16517606}.

Transmembrane domains:

  1. 783-803, 21 AA, Helical. {ECO:0000255}.

Sequence: 827 AA

10 20 30 40 50 60 MAFPHLQQPS FLLASLKADS INKPFAQQCQ DLVKVIEDFP AKELHTIFPW LVESIFGSLD 70 80 90 100 110 120 GVLVGWNLRC LQGRVNPVEY SIVMEFLDPG GPMMKLVYKL QAEDYKFDFP VSYLPGPVKA 130 140 150 160 170 180 SIQECILPDS PLYHNKVQFT PTGGLGLNLA LNPFEYYIFF FALSLITQKP LPVSLHVRTS 190 200 210 220 230 240 DCAYFILVDR YLSWFLPTEG SVPPPLSSSP GGTSPSPPPR TPAIPFASYG LHHTSLLKRH 250 260 270 280 290 300 ISHQTSVNAD PASHEIWRSE TLLQVFVEMW LHHYSLEMYQ KMQSPHAKLE VLHYRLSVSS 310 320 330 340 350 360 ALYSPAQPSL QALHAYQESF TPTEEHVLVV RLLLKHLHAF ANSLKPEQAS PSAHSHATSP 370 380 390 400 410 420 LEEFKRAAVP RFVQQKLYLF LQHCFGHWPL DASFRAVLEM WLSYLQPWRY APDKQAPGSD 430 440 450 460 470 480 SQPRCVSEKW APFVQENLLM YTKLFVGFLN RALRTDLVSP KHALMVFRVA KVFAQPNLAE 490 500 510 520 530 540 MIQKGEQLFL EPELVIPHRQ HRLFTAPTFT GSFLSPWPPA VTDASFKVKS HVYSLEGQDC 550 560 570 580 590 600 KYTPMFGPEA RTLVLRLAQL ITQAKHTAKS ISDQCAESPA GHSFLSWLGF SSMDTNGSYT 610 620 630 640 650 660 ANDLDEMGQD SVRKTDEYLE KALEYLRQIF RLSEAQLRQF TLALGTTQDE NGKKQLPDCI 670 680 690 700 710 720 VGEDGLILTP LGRYQIINGL RRFEIEYQGD PELQPIRSYE IASLVRTLFR LSSAINHRFA 730 740 750 760 770 780 GQMAALCSRD DFLGSFCRYH LTEPGLASRH LLSPVGRRQV AGHTRGPRLS LRFLGSYRTL 790 800 810 820 VSLLLAFFVA SLFCVGPLPC TLLLTLGYVL YASAMTLLTE RGKLHQP

CATM prediction

The sequence of NSMA3_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  780       790       800    
|    +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 LVSLLLAFFVASLFCVGALACTLLLTL 7.0 -55.1° 1.5 45.0 -23.4
Prolines* LVSLLLAFFVASLFCVGPLPCTLLLTL          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 796, GLY, HA1 A, 793, PHE, O 2.96Å
B, 797, ALA, HA A, 796, GLY, O 3.48Å
A, 796, GLY, HA1 B, 793, PHE, O 2.96Å
A, 797, ALA, HA B, 796, GLY, O 3.48Å