Inositol monophosphatase 3

UniProt data

UniProt name: IMPA3_HUMAN (Q9NX62)

Gene name: IMPAD1; Synonyms=IMPA3

Organism: Homo sapiens (Human).

Function: May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation. {ECO:0000250}.

Subcellular location: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:18695242}; Single-pass type II membrane protein {ECO:0000269|PubMed:18695242}.

Transmembrane domains:

  1. 13-33, 21 AA, Helical. {ECO:0000255}.

Sequence: 359 AA

10 20 30 40 50 60 MAPMGIRLSP LGVAVFCLLG LGVLYHLYSG FLAGRFSLFG LGGEPGGGAA GPAAAADGGT 70 80 90 100 110 120 VDLREMLAVS VLAAVRGGDE VRRVRESNVL HEKSKGKTRE GAEDKMTSGD VLSNRKMFYL 130 140 150 160 170 180 LKTAFPSVQI NTEEHVDAAD QEVILWDHKI PEDILKEVTT PKEVPAESVT VWIDPLDATQ 190 200 210 220 230 240 EYTEDLRKYV TTMVCVAVNG KPMLGVIHKP FSEYTAWAMV DGGSNVKARS SYNEKTPRIV 250 260 270 280 290 300 VSRSHSGMVK QVALQTFGNQ TTIIPAGGAG YKVLALLDVP DKSQEKADLY IHVTYIKKWD 310 320 330 340 350 ICAGNAILKA LGGHMTTLSG EEISYTGSDG IEGGLLASIR MNHQALVRKL PDLEKTGHK

CATM prediction

The sequence of IMPA3_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  10        20        30     
|    +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 ALGVAVFCLLGLGVLYHLYSGFLAGRF 6.6 -37.0° 0.3 44.2 -29.6
Model 2 ALGVAVFCLLGLGVLYHLYSGFLAGRF 6.9 -54.7° 0.9 50.3 -8.5
Prolines* PLGVAVFCLLGLGVLYHLYSGFLAGRF          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 27, LEU, HA A, 26, HSE, O 3.10Å
B, 30, GLY, HA1 A, 27, LEU, O 2.73Å
B, 31, PHE, HA A, 30, GLY, O 2.50Å
A, 27, LEU, HA B, 26, HSE, O 3.10Å
A, 30, GLY, HA1 B, 27, LEU, O 2.73Å
A, 31, PHE, HA B, 30, GLY, O 2.50Å