HRAS-like suppressor 2

UniProt data

UniProt name: HRSL2_HUMAN (Q9NWW9)

Gene name: HRASLS2

Organism: Homo sapiens (Human).

Function: Exhibits PLA1/2 activity, catalyzing the calcium- independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. Catalyzes N-acylation of PE using both sn-1 and sn-2 palmitoyl groups of PC as acyl donor. Also catalyzes O-acylation converting lyso-PC into PC. {ECO:0000269|PubMed:19615464}.

Subcellular location: Cytoplasm. Membrane; Single-pass membrane protein. Note=Exhibits a granular pattern in the cytoplasm with preferential perinuclear localization.

Transmembrane domains:

  1. 133-155, 23 AA, Helical. {ECO:0000255}.

Sequence: 162 AA

10 20 30 40 50 60 MALARPRPRL GDLIEISRFG YAHWAIYVGD GYVVHLAPAS EIAGAGAASV LSALTNKAIV 70 80 90 100 110 120 KKELLSVVAG GDNYRVNNKH DDRYTPLPSN KIVKRAEELV GQELPYSLTS DNCEHFVNHL 130 140 150 160 RYGVSRSDQV TGAVTTVGVA AGLLAAASLV GILLARSKRE RQ

CATM prediction

The sequence of HRSL2_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  130       140       150      
|    +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 VTGAVTTVGVAAGLLAAASLVGILLARSK 6.9 -43.0° 2.4 43.9 -32.3
Model 2 VTGAVTTVGVAAGLLAAASLVGILLARSK 6.4 -45.3° 4.4 54.9 -27.4
Model 3 VTGAVTTVGVAAGLLAAASLVGILLARSK 7.1 -55.0° 0.9 50.1 -6.8

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 148, SER, HA A, 147, ALA, O 3.01Å
B, 151, GLY, HA1 A, 148, SER, O 2.87Å
B, 152, ILE, HA A, 151, GLY, O 3.30Å
A, 148, SER, HA B, 147, ALA, O 3.01Å
A, 151, GLY, HA1 B, 148, SER, O 2.87Å
A, 152, ILE, HA B, 151, GLY, O 3.30Å