Protein FAM118A

UniProt data

UniProt name: F118A_HUMAN (Q9NWS6)

Gene name: FAM118A; Synonyms=C22orf8

Organism: Homo sapiens (Human).

Function:

Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 30-50, 21 AA, Helical. {ECO:0000255}.

Sequence: 357 AA

10 20 30 40 50 60 MDSVEKTTNR SEQKSRKFLK SLIRKQPQEL LLVIGTGVSA AVAPGIPALC SWRSCIEAVI 70 80 90 100 110 120 EAAEQLEVLH PGDVAEFRRK VTKDRDLLVV AHDLIRKMSP RTGDAKPSFF QDCLMEVFDD 130 140 150 160 170 180 LEQHIRSPVV LQSILSLMDR GAMVLTTNYD NLLEAFGRRQ NKPMESLDLK DKTKVLEWAR 190 200 210 220 230 240 GHMKYGVLHI HGLYTDPCGV VLDPSGYKDV TQDAEVMEVL QNLYRTKSFL FVGCGETLRD 250 260 270 280 290 300 QIFQALFLYS VPNKVDLEHY MLVLKENEDH FFKHQADMLL HGIKVVSYGD CFDHFPGYVQ 310 320 330 340 350 DLATQICKQQ SPDADRVDST TLLGNACQDC AKRKLEENGI EVSKKRTQSD TDDAGGS

CATM prediction

The sequence of F118A_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     30        40        50  
   |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 AQELLLVIGTGVSAAVAAGIAALCSWR 7.2 -37.0° 2.3 35.6 -2.2
Model 2 AQELLLVIGTGVSAAVAAGIAALCSWR 7.2 -37.0° 2.2 36.3 -1.3
Prolines* PQELLLVIGTGVSAAVAPGIPALCSWR          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 44, ALA, HA A, 43, ALA, O 3.48Å
B, 48, ALA, HA A, 47, ALA, O 3.41Å
A, 44, ALA, HA B, 43, ALA, O 3.48Å
A, 48, ALA, HA B, 47, ALA, O 3.41Å