Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

UniProt data

UniProt name: PHAG1_HUMAN (Q9NWQ8)

Gene name: PAG1; Synonyms=CBP, PAG

Organism: Homo sapiens (Human).

Function: Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. {ECO:0000269|PubMed:10790433}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:10790433, ECO:0000269|PubMed:18070987}; Single-pass type III membrane protein {ECO:0000269|PubMed:10790433, ECO:0000269|PubMed:18070987}. Note=Present in lipid rafts.

Transmembrane domains:

  1. 17-37, 21 AA, Helical; Signal-anchor for type III membrane protein. {ECO:0000255}.

Sequence: 432 AA

10 20 30 40 50 60 MGPAGSLLGS GQMQITLWGS LAAVAIFFVI TFLIFLCSSC DREKKPRQHS GDHENLMNVP 70 80 90 100 110 120 SDKEMFSRSV TSLATDAPAS SEQNGALTNG DILSEDSTLT CMQHYEEVQT SASDLLDSQD 130 140 150 160 170 180 STGKPKCHQS RELPRIPPES AVDTMLTARS VDGDQGLGME GPYEVLKDSS SQENMVEDCL 190 200 210 220 230 240 YETVKEIKEV AAAAHLEKGH SGKAKSTSAS KELPGPQTEG KAEFAEYASV DRNKKCRQSV 250 260 270 280 290 300 NVESILGNSC DPEEEAPPPV PVKLLDENEN LQEKEGGEAE ESATDTTSET NKRFSSLSYK 310 320 330 340 350 360 SREEDPTLTE EEISAMYSSV NKPGQLVNKS GQSLTVPEST YTSIQGDPQR SPSSCNDLYA 370 380 390 400 410 420 TVKDFEKTPN STLPPAGRPS EEPEPDYEAI QTLNREEEKA TLGTNGHHGL VPKENDYESI 430 SDLQQGRDIT RL

CATM prediction

The sequence of PHAG1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        20        30        4
 +    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 QITLWGSLAAVAIFFVITFLIFLCSSC 7.2 -49.0° 1.8 45.0 -3.2

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session