ATPase family AAA domain-containing protein 3A

UniProt data

UniProt name: ATD3A_HUMAN (Q9NVI7)

Gene name: ATAD3A

Organism: Homo sapiens (Human).

Function: Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level. May play an important in mitochondrial protein synthesis. May also participate in mitochondrial DNA replication. May bind to mitochondrial DNA D-loops and contribute to nucleoid stability. Required for enhanced channeling of cholesterol for hormone- dependent steroidogenesis. {ECO:0000269|PubMed:17210950, ECO:0000269|PubMed:20154147, ECO:0000269|PubMed:22453275}.

Subcellular location: Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion matrix, mitochondrion nucleoid. Note=In the mitochondrial inner membrane, enriched in sites with the potential to form contacts with the outer membrane. The N- terminal domain interacts with the inner surface of the mitochondrial outer membrane and the C-terminal domain localizes in a specific matrix compartment, where it is associated with nucleoids.

Transmembrane domains:

  1. 295-312, 18 AA, Helical. {ECO:0000255}.

Sequence: 634 AA

10 20 30 40 50 60 MSWLFGINKG PKGEGAGPPP PLPPAQPGAE GGGDRGLGDR PAPKDKWSNF DPTGLERAAK 70 80 90 100 110 120 AARELEHSRY AKDALNLAQM QEQTLQLEQQ SKLKMRLEAL SLLHTLVWAW SLCRAGAVQT 130 140 150 160 170 180 QERLSGSASP EQVPAGECCA LQEYEAAVEQ LKSEQIRAQA EERRKTLSEE TRQHQARAQY 190 200 210 220 230 240 QDKLARQRYE DQLKQQQLLN EENLRKQEES VQKQEAMRRA TVEREMELRH KNEMLRVEAE 250 260 270 280 290 300 ARARAKAERE NADIIREQIR LKAAEHRQTV LESIRTAGTL FGEGFRAFVT DWDKVTATVA 310 320 330 340 350 360 GLTLLAVGVY SAKNATLVAG RFIEARLGKP SLVRETSRIT VLEALRHPIQ VSRRLLSRPQ 370 380 390 400 410 420 DALEGVVLSP SLEARVRDIA IATRNTKKNR SLYRNILMYG PPGTGKTLFA KKLALHSGMD 430 440 450 460 470 480 YAIMTGGDVA PMGREGVTAM HKLFDWANTS RRGLLLFVDE ADAFLRKRAT EKISEDLRAT 490 500 510 520 530 540 LNAFLYRTGQ HSNKFMLVLA SNQPEQFDWA INDRINEMVH FDLPGQEERE RLVRMYFDKY 550 560 570 580 590 600 VLKPATEGKQ RLKLAQFDYG RKCSEVARLT EGMSGREIAQ LAVSWQATAY ASEDGVLTEA 610 620 630 MMDTRVQDAV QQHQQKMCWL KAEGPGRGDE PSPS

CATM prediction

The sequence of ATD3A_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          300       310   
   +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 WDKVTATVAGLTLLAVGVYSAKNA 7.4 -36.0° 3.6 35.8 -27.6
Model 2 WDKVTATVAGLTLLAVGVYSAKNA 7.4 -48.1° 0.5 46.8 -11.0

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 305, LEU, HA A, 304, LEU, O 3.44Å
B, 308, GLY, HA1 A, 305, LEU, O 3.47Å
A, 305, LEU, HA B, 304, LEU, O 3.44Å
A, 308, GLY, HA1 B, 305, LEU, O 3.47Å