Leucine-rich repeat-containing protein 4B

UniProt data

UniProt name: LRC4B_HUMAN (Q9NT99)

Gene name: LRRC4B; Synonyms=LRIG4

Organism: Homo sapiens (Human).

Function: Synaptic adhesion protein. Regulates the formation of excitatory synapses. The trans-synaptic adhesion between LRRC4B and PTPRF regulates the formation of excitatory synapses in a bidirectional manner (By similarity). {ECO:0000250}.

Subcellular location: Membrane; Single-pass membrane protein. Cell junction, synapse, presynaptic cell membrane {ECO:0000250}.

Transmembrane domains:

  1. 577-597, 21 AA, Helical. {ECO:0000255}.

Sequence: 713 AA

10 20 30 40 50 60 MARARGSPCP PLPPGRMSWP HGALLFLWLF SPPLGAGGGG VAVTSAAGGG SPPATSCPVA 70 80 90 100 110 120 CSCSNQASRV ICTRRDLAEV PASIPVNTRY LNLQENGIQV IRTDTFKHLR HLEILQLSKN 130 140 150 160 170 180 LVRKIEVGAF NGLPSLNTLE LFDNRLTTVP TQAFEYLSKL RELWLRNNPI ESIPSYAFNR 190 200 210 220 230 240 VPSLRRLDLG ELKRLEYISE AAFEGLVNLR YLNLGMCNLK DIPNLTALVR LEELELSGNR 250 260 270 280 290 300 LDLIRPGSFQ GLTSLRKLWL MHAQVATIER NAFDDLKSLE ELNLSHNNLM SLPHDLFTPL 310 320 330 340 350 360 HRLERVHLNH NPWHCNCDVL WLSWWLKETV PSNTTCCARC HAPAGLKGRY IGELDQSHFT 370 380 390 400 410 420 CYAPVIVEPP TDLNVTEGMA AELKCRTGTS MTSVNWLTPN GTLMTHGSYR VRISVLHDGT 430 440 450 460 470 480 LNFTNVTVQD TGQYTCMVTN SAGNTTASAT LNVSAVDPVA AGGTGSGGGG PGGSGGVGGG 490 500 510 520 530 540 SGGYTYFTTV TVETLETQPG EEALQPRGTE KEPPGPTTDG VWGGGRPGDA AGPASSSTTA 550 560 570 580 590 600 PAPRSSRPTE KAFTVPITDV TENALKDLDD VMKTTKIIIG CFVAITFMAA VMLVAFYKLR 610 620 630 640 650 660 KQHQLHKHHG PTRTVEIINV EDELPAASAV SVAAAAAVAS GGGVGGDSHL ALPALERDHL 670 680 690 700 710 NHHHYVAAAF KAHYSSNPSG GGCGGKGPPG LNSIHEPLLF KSGSKENVQE TQI

CATM prediction

The sequence of LRC4B_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        580       590       6
 +    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 TTKIIIGCFVAITFMAAVMLVAFYKLR 7.0 -47.6° 2.3 44.9 -27.3

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 580, GLY, HA1 A, 577, ILE, O 2.91Å
B, 581, CYS, HA A, 580, GLY, O 3.36Å
A, 580, GLY, HA1 B, 577, ILE, O 2.91Å
A, 581, CYS, HA B, 580, GLY, O 3.36Å