Patatin-like phospholipase domain-containing protein 3

UniProt data

UniProt name: PLPL3_HUMAN (Q9NST1)

Gene name: PNPLA3; Synonyms=ADPN, C22orf20

Organism: Homo sapiens (Human).

Function: Multifunctional enzyme which has both triacylglycerol lipase and acylglycerol O-acyltransferase activities. {ECO:0000269|PubMed:15364929}.

Subcellular location: Membrane {ECO:0000269|PubMed:15364929}; Single-pass type II membrane protein {ECO:0000269|PubMed:15364929}.

Transmembrane domains:

  1. 42-62, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 481 AA

10 20 30 40 50 60 MYDAERGWSL SFAGCGFLGF YHVGATRCLS EHAPHLLRDA RMLFGASAGA LHCVGVLSGI 70 80 90 100 110 120 PLEQTLQVLS DLVRKARSRN IGIFHPSFNL SKFLRQGLCK CLPANVHQLI SGKIGISLTR 130 140 150 160 170 180 VSDGENVLVS DFRSKDEVVD ALVCSCFIPF YSGLIPPSFR GVRYVDGGVS DNVPFIDAKT 190 200 210 220 230 240 TITVSPFYGE YDICPKVKST NFLHVDITKL SLRLCTGNLY LLSRAFVPPD LKVLGEICLR 250 260 270 280 290 300 GYLDAFRFLE EKGICNRPQP GLKSSSEGMD PEVAMPSWAN MSLDSSPESA ALAVRLEGDE 310 320 330 340 350 360 LLDHLRLSIL PWDESILDTL SPRLATALSE EMKDKGGYMS KICNLLPIRI MSYVMLPCTL 370 380 390 400 410 420 PVESAIAIVQ RLVTWLPDMP DDVLWLQWVT SQVFTRVLMC LLPASRSQMP VSSQQASPCT 430 440 450 460 470 480 PEQDWPCWTP CSPKGCPAET KAEATPRSIL RSSLNFFLGN KVPAGAEGLS TFPSFSLEKS L

CATM prediction

The sequence of PLPL3_HUMAN returned 6 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
   40        50        60    
 |    +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 DARMLFGASAGALHCVGVLSGIALEQT 6.9 -28.1° 3.2 47.8 -34.9
Model 2 DARMLFGASAGALHCVGVLSGIALEQT 6.5 -45.0° 5.5 45.0 -29.9
Model 3 DARMLFGASAGALHCVGVLSGIALEQT 6.8 -48.0° 0.8 54.0 -24.5
Model 4 DARMLFGASAGALHCVGVLSGIALEQT 7.2 -48.1° 0.4 47.3 -15.9
Model 5 DARMLFGASAGALHCVGVLSGIALEQT 6.9 -51.3° 3.3 47.8 -13.8
Model 6 DARMLFGASAGALHCVGVLSGIALEQT 7.1 -38.0° 5.7 34.0 -11.2
Prolines* DARMLFGASAGALHCVGVLSGIPLEQT          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 45, GLY, HA1 A, 42, MET, O 3.07Å
B, 46, ALA, HA A, 45, GLY, O 3.23Å
A, 45, GLY, HA1 B, 42, MET, O 3.07Å
A, 46, ALA, HA B, 45, GLY, O 3.23Å