Protein C19orf12

UniProt data

UniProt name: CS012_HUMAN (Q9NSK7)

Gene name: C19orf12

Organism: Homo sapiens (Human).

Function:

Subcellular location: Mitochondrion {ECO:0000269|PubMed:21981780, ECO:0000269|PubMed:22508347, ECO:0000269|PubMed:26136767}. Mitochondrion membrane {ECO:0000269|PubMed:21981780, ECO:0000269|PubMed:26136767}; Single-pass membrane protein {ECO:0000255}. Endoplasmic reticulum {ECO:0000269|PubMed:22508347}. Cytoplasm, cytosol {ECO:0000269|PubMed:26136767}. Note=In response to oxidative stress, relocates to the cytosol forming aggregates that partially co-localize with mitochondria. {ECO:0000269|PubMed:26136767}.

Transmembrane domains:

  1. 51-71, 21 AA, Helical. {ECO:0000255}.

Sequence: 152 AA

10 20 30 40 50 60 MERLKSHKPA TMTIMVEDIM KLLCSLSGER KMKAAVKHSG KGALVTGAMA FVGGLVGGPP 70 80 90 100 110 120 GLAVGGAVGG LLGAWMTSGQ FKPVPQILME LPPAEQQRLF NEAAAIIRHL EWTDAVQLTA 130 140 150 LVMGSEALQQ QLLAMLVNYV TKELRAEIQY DD

CATM prediction

The sequence of CS012_HUMAN returned 21 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    50        60        70   
  |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 AMAFVGGLVGGAAGLAVGGAVGGLLGA 6.4 -29.1° 4.7 51.7 -45.7
Model 2 AMAFVGGLVGGAAGLAVGGAVGGLLGA 6.5 -31.2° 4.1 50.8 -44.7
Model 3 AMAFVGGLVGGAAGLAVGGAVGGLLGA 6.5 -35.1° 0.7 44.3 -42.0
Model 4 AMAFVGGLVGGAAGLAVGGAVGGLLGA 6.7 -34.0° 4.1 62.0 -34.7
Model 5 AMAFVGGLVGGAAGLAVGGAVGGLLGA 6.7 -42.9° 3.0 34.9 -32.8
Model 6 AMAFVGGLVGGAAGLAVGGAVGGLLGA 6.5 -30.1° 3.5 52.8 -30.6
Model 7 AMAFVGGLVGGAAGLAVGGAVGGLLGA 7.0 -30.0° 3.5 53.0 -28.5
Model 8 AMAFVGGLVGGAAGLAVGGAVGGLLGA 6.4 -51.0° 0.2 44.9 -28.1
Model 9 AMAFVGGLVGGAAGLAVGGAVGGLLGA 6.4 -45.1° 0.2 44.9 -27.7
Model 10 AMAFVGGLVGGAAGLAVGGAVGGLLGA 6.5 -48.8° 1.8 45.1 -27.4
Model 11 AMAFVGGLVGGAAGLAVGGAVGGLLGA 6.3 -47.8° 0.5 46.9 -26.3
Model 12 AMAFVGGLVGGAAGLAVGGAVGGLLGA 6.6 -51.1° 2.4 45.1 -21.3
Model 13 AMAFVGGLVGGAAGLAVGGAVGGLLGA 6.4 -54.1° 3.0 62.0 -20.9
Model 14 AMAFVGGLVGGAAGLAVGGAVGGLLGA 6.3 -43.2° 3.9 53.8 -20.5
Model 15 AMAFVGGLVGGAAGLAVGGAVGGLLGA 6.4 -44.1° 0.9 45.8 -14.6
Model 16 AMAFVGGLVGGAAGLAVGGAVGGLLGA 6.7 -48.0° 0.0 38.0 -11.8
Model 17 AMAFVGGLVGGAAGLAVGGAVGGLLGA 7.1 -26.0° 3.6 54.0 -11.7
Model 18 AMAFVGGLVGGAAGLAVGGAVGGLLGA 6.5 +53.1° 2.7 88.0 -10.0
Model 19 AMAFVGGLVGGAAGLAVGGAVGGLLGA 7.1 -53.9° 2.6 32.8 -8.5
Model 20 AMAFVGGLVGGAAGLAVGGAVGGLLGA 7.0 +53.9° 3.3 80.2 -3.7
Model 21 AMAFVGGLVGGAAGLAVGGAVGGLLGA 7.1 -40.0° 2.7 34.1 -3.3
Prolines* AMAFVGGLVGGPPGLAVGGAVGGLLGA          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 58, GLY, HA2 A, 57, GLY, O 3.03Å
B, 61, GLY, HA1 A, 58, GLY, O 2.75Å
B, 62, LEU, HA A, 61, GLY, O 2.25Å
B, 65, GLY, HA1 A, 62, LEU, O 2.97Å
B, 66, GLY, HA2 A, 65, GLY, O 3.42Å
A, 58, GLY, HA2 B, 57, GLY, O 3.03Å
A, 61, GLY, HA1 B, 58, GLY, O 2.75Å
A, 62, LEU, HA B, 61, GLY, O 2.25Å
A, 65, GLY, HA1 B, 62, LEU, O 2.97Å
A, 66, GLY, HA2 B, 65, GLY, O 3.42Å