Immunoglobulin superfamily member 5

UniProt data

UniProt name: IGSF5_HUMAN (Q9NSI5)

Gene name: IGSF5; Synonyms=JAM4

Organism: Homo sapiens (Human).

Function: Provides, together with MAGI1, an adhesion machinery at tight junctions, which may regulate the permeability of kidney glomerulus and small intestinal epithelial cells. Mediates calcium-independent homophilic cell adhesion. In testis, it may function as a cell adhesion molecule rather than a tight-junction protein. It may participate in the adhesion between spermatogonia- spermatogonia, spermatogonia-Sertoli cells, and Sertoli cells- Sertoli cells (By similarity). {ECO:0000250}.

Subcellular location: Apical cell membrane {ECO:0000250|UniProtKB:Q5VJ70}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q5VJ70}.

Transmembrane domains:

  1. 267-285, 19 AA, Helical. {ECO:0000255}.

Sequence: 407 AA

10 20 30 40 50 60 MGQKERSTAD TLPDLEEWKS AAGLRWWQTA VVDGSGSGNE VIEGPQNARV LKGSQARFNC 70 80 90 100 110 120 TVSQGWKLIM WALSDMVVLS VRPMEPIITN DRFTSQRYDQ GGNFTSEMII HNVEPSDSGN 130 140 150 160 170 180 IRCSLQNSRL HGSAYLTVQV MGELFIPSVN LVVAENEPCE VTCLPSHWTR LPDISWELGL 190 200 210 220 230 240 LVSHSSYYFV PEPSDLQSAV SILALTPQSN GTLTCVATWK SLKARKSATV NLTVIRCPQD 250 260 270 280 290 300 TGGGINIPGV LSSLPSLGFS LPTWGKVGLG LAGTMLLTPT CTLTIRCCCC RRRCCGCNCC 310 320 330 340 350 360 CRCCFCCRRK RGFRIQFQKK SEKEKTNKET ETESGNENSG YNSDEQKTTD TASLPPKSCE 370 380 390 400 SSDPEQRNSS CGPPHQRADQ RPPRPASHPQ ASFNLASPEK VSNTTVV

CATM prediction

The sequence of IGSF5_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        270       280      
 +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 WGKVGLGLAGTMLLTATCTLTIRCC 7.3 -49.9° 2.9 46.8 -8.7
Model 2 WGKVGLGLAGTMLLTATCTLTIRCC 7.1 -38.0° 5.7 34.0 -7.7
Prolines* WGKVGLGLAGTMLLTPTCTLTIRCC          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 270, GLY, HA1 A, 267, VAL, O 3.28Å
B, 271, LEU, HA A, 274, THR, OG1 2.69Å
A, 270, GLY, HA1 B, 267, VAL, O 3.28Å
A, 271, LEU, HA B, 274, THR, OG1 2.69Å