UniProt data
UniProt name: THSD1_HUMAN (Q9NS62)
Gene name: THSD1; Synonyms=TMTSP; ORFNames=UNQ3010/PRO9769
Organism: Homo sapiens (Human).
Function:
Subcellular location: Isoform 3: Secreted.
Transmembrane domains:
- 414-434, 21 AA, Helical. {ECO:0000255}.
Sequence: 852 AA
10 20 30 40 50 60
MKPMLKDFSN LLLVVLCDYV LGEAEYLLLR EPGHVALSND TVYVDFQYFD GANGTLRNVS
70 80 90 100 110 120
VLLLEANTNQ TVTTKYLLTN QSQGTLKFEC FYFKEAGDYW FTMTPEATDN STPFPWWEKS
130 140 150 160 170 180
AFLKVEWPVF HVDLNRSAKA AEGTFQVGLF TSQPLCPFPV DKPNIVVDVI FTNSLPEARR
190 200 210 220 230 240
NSRQPLEIRT SKRTELAQGQ WVEFGCAPLG PEAYVTVVLK LLGRDSVITS TGPIDLAQKF
250 260 270 280 290 300
GYKLVMVPEL TCESGVEVTV LPPPCTFVQG VVTVFKEAPR YPGKRTIHLA ENSLPLGERR
310 320 330 340 350 360
TIFNCTLFDM GKNKYCFDFG ISSRSHFSAK EECMLIQRNT ETWGLWQPWS QCSATCGDGV
370 380 390 400 410 420
RERRRVCLTS FPSSPVCPGM SLEASLCSLE ECAAFQPSSP SPLQPQGPVK SNNIVTVTGI
430 440 450 460 470 480
SLCLFIIIAT VLITLWRRFG RPAKCSTPAR HNSIHSPSFR KNSDEENICE LSEQRGSFSD
490 500 510 520 530 540
GGDGPTGSPG DTGIPLTYRR SGPVPPEDDA SGSESFQSNA QKIIPPLFSY RLAQQQLKEM
550 560 570 580 590 600
KKKGLTETTK VYHVSQSPLT DTAIDAAPSA PLDLESPEEA AANKFRIKSP FPEQPAVSAG
610 620 630 640 650 660
ERPPSRLDLN VTQASCAISP SQTLIRKSQA RHVGSRGGPS ERSHARNAHF RRTASFHEAR
670 680 690 700 710 720
QARPFRERSM STLTPRQAPA YSSRTRTCEQ AEDRFRPQSR GAHLFPEKLE HFQEASGTRG
730 740 750 760 770 780
PLNPLPKSYT LGQPLRKPDL GDHQAGLVAG IERTEPHRAR RGPSPSHKSV SRKQSSPISP
790 800 810 820 830 840
KDNYQRVSSL SPSQCRKDKC QSFPTHPEFA FYDNTSFGLT EAEQRMLDLP GYFGSNEEDE
850
TTSTLSVEKL VI
CATM prediction
The sequence of THSD1_HUMAN returned 1 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 420 430 + | + | + |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | SNNIVTVTGISLCLFIIIATVLITLWR | 7.2 | -48.9° | 1.8 | 44.7 | -14.6 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 416, THR, HA | A, 415, VAL, O | 3.32Å |
| B, 419, GLY, HA1 | A, 416, THR, O | 2.96Å |
| B, 420, ILE, HA | A, 419, GLY, O | 3.30Å |
| A, 416, THR, HA | B, 415, VAL, O | 3.32Å |
| A, 419, GLY, HA1 | B, 416, THR, O | 2.96Å |
| A, 420, ILE, HA | B, 419, GLY, O | 3.30Å |