Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1

UniProt data

UniProt name: C1GLT_HUMAN (Q9NS00)

Gene name: C1GALT1

Organism: Homo sapiens (Human).

Function: Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development.

Subcellular location: Membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Transmembrane domains:

  1. 7-29, 23 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 363 AA

10 20 30 40 50 60 MASKSWLNFL TFLCGSAIGF LLCSQLFSIL LGEKVDTQPN VLHNDPHARH SDDNGQNHLE 70 80 90 100 110 120 GQMNFNADSS QHKDENTDIA ENLYQKVRIL CWVMTGPQNL EKKAKHVKAT WAQRCNKVLF 130 140 150 160 170 180 MSSEENKDFP AVGLKTKEGR DQLYWKTIKA FQYVHEHYLE DADWFLKADD DTYVILDNLR 190 200 210 220 230 240 WLLSKYDPEE PIYFGRRFKP YVKQGYMSGG AGYVLSKEAL KRFVDAFKTD KCTHSSSIED 250 260 270 280 290 300 LALGRCMEIM NVEAGDSRDT IGKETFHPFV PEHHLIKGYL PRTFWYWNYN YYPPVEGPGC 310 320 330 340 350 360 CSDLAVSFHY VDSTTMYELE YLVYHLRPYG YLYRYQPTLP ERILKEISQA NKNEDTKVKL GNP

CATM prediction

The sequence of C1GLT_HUMAN returned 4 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        10        20        30 
 +    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 KSWLNFLTFLCGSAIGFLLCSQLFSILLG 6.6 -41.1° 3.5 37.4 -48.9
Model 2 KSWLNFLTFLCGSAIGFLLCSQLFSILLG 7.1 -42.1° 1.4 44.9 -36.4
Model 3 KSWLNFLTFLCGSAIGFLLCSQLFSILLG 7.1 -51.0° 1.2 45.6 -21.4
Model 4 KSWLNFLTFLCGSAIGFLLCSQLFSILLG 7.1 -54.0° 3.0 61.7 -21.0

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 16, SER, HA A, 15, GLY, O 2.60Å
B, 19, GLY, HA1 A, 16, SER, O 2.57Å
B, 20, PHE, HA A, 19, GLY, O 3.09Å
A, 16, SER, HA B, 15, GLY, O 2.60Å
A, 19, GLY, HA1 B, 16, SER, O 2.57Å
A, 20, PHE, HA B, 19, GLY, O 3.09Å