Tryptase gamma

UniProt data

UniProt name: TRYG1_HUMAN (Q9NRR2)

Gene name: TPSG1; Synonyms=PRSS31, TMT

Organism: Homo sapiens (Human).

Function:

Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 284-304, 21 AA, Helical. {ECO:0000255}.

Sequence: 321 AA

10 20 30 40 50 60 MALGACGLLL LLAVPGVSLR TLQPGCGRPQ VSDAGGRIVG GHAAPAGAWP WQASLRLRRM 70 80 90 100 110 120 HVCGGSLLSP QWVLTAAHCF SGSLNSSDYQ VHLGELEITL SPHFSTVRQI ILHSSPSGQP 130 140 150 160 170 180 GTSGDIALVE LSVPVTLSSR ILPVCLPEAS DDFCPGIRCW VTGWGYTREG EPLPPPYSLR 190 200 210 220 230 240 EVKVSVVDTE TCRRDYPGPG GSILQPDMLC ARGPGDACQD DSGGPLVCQV NGAWVQAGTV 250 260 270 280 290 300 SWGEGCGRPN RPGVYTRVPA YVNWIRRHIT ASGGSESGYP RLPLLAGLFL PGLFLLLVSC 310 320 VLLAKCLLHP SADGTPFPAP D

CATM prediction

The sequence of TRYG1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
           290       300     
    +    |    +    |    +  		 (Å) (°) (Å) (°)  
Model 1 RLALLAGLFLAGLFLLLVSCVLLAKCL 7.0 -40.0° 4.5 44.0 -17.8
Prolines* RLPLLAGLFLPGLFLLLVSCVLLAKCL          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 287, GLY, HA1 A, 284, LEU, O 3.19Å
A, 287, GLY, HA1 B, 284, LEU, O 3.19Å