Delta-like protein 4

UniProt data

UniProt name: DLL4_HUMAN (Q9NR61)

Gene name: DLL4; ORFNames=UNQ1895/PRO4341

Organism: Homo sapiens (Human).

Function: Involved in the Notch signaling pathway as Notch ligand (PubMed:11134954). Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting (PubMed:20616313). Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types (By similarity). During spinal cord neurogenesis, inhibits V2a interneuron fate (PubMed:17728344). {ECO:0000250|UniProtKB:Q9JI71, ECO:0000269|PubMed:11134954, ECO:0000269|PubMed:17728344, ECO:0000269|PubMed:20616313}.

Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 530-550, 21 AA, Helical. {ECO:0000255}.

Sequence: 685 AA

10 20 30 40 50 60 MAAASRSASG WALLLLVALW QQRAAGSGVF QLQLQEFINE RGVLASGRPC EPGCRTFFRV 70 80 90 100 110 120 CLKHFQAVVS PGPCTFGTVS TPVLGTNSFA VRDDSSGGGR NPLQLPFNFT WPGTFSLIIE 130 140 150 160 170 180 AWHAPGDDLR PEALPPDALI SKIAIQGSLA VGQNWLLDEQ TSTLTRLRYS YRVICSDNYY 190 200 210 220 230 240 GDNCSRLCKK RNDHFGHYVC QPDGNLSCLP GWTGEYCQQP ICLSGCHEQN GYCSKPAECL 250 260 270 280 290 300 CRPGWQGRLC NECIPHNGCR HGTCSTPWQC TCDEGWGGLF CDQDLNYCTH HSPCKNGATC 310 320 330 340 350 360 SNSGQRSYTC TCRPGYTGVD CELELSECDS NPCRNGGSCK DQEDGYHCLC PPGYYGLHCE 370 380 390 400 410 420 HSTLSCADSP CFNGGSCRER NQGANYACEC PPNFTGSNCE KKVDRCTSNP CANGGQCLNR 430 440 450 460 470 480 GPSRMCRCRP GFTGTYCELH VSDCARNPCA HGGTCHDLEN GLMCTCPAGF SGRRCEVRTS 490 500 510 520 530 540 IDACASSPCF NRATCYTDLS TDTFVCNCPY GFVGSRCEFP VGLPPSFPWV AVSLGVGLAV 550 560 570 580 590 600 LLVLLGMVAV AVRQLRLRRP DDGSREAMNN LSDFQKDNLI PAAQLKNTNQ KKELEVDCGL 610 620 630 640 650 660 DKSNCGKQQN HTLDYNLAPG PLGRGTMPGK FPHSDKSLGE KAPLRLHSEK PECRISAICS 670 680 PRDSMYQSVC LISEERNECV IATEV

CATM prediction

The sequence of DLL4_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     530       540       550 
   |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 FAWVAVSLGVGLAVLLVLLGMVAVAVR 6.9 -46.0° 2.7 46.8 -28.5
Prolines* FPWVAVSLGVGLAVLLVLLGMVAVAVR          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 532, VAL, HA A, 531, ALA, O 2.86Å
B, 535, GLY, HA1 A, 532, VAL, O 2.82Å
B, 536, VAL, HA A, 535, GLY, O 3.42Å
A, 532, VAL, HA B, 531, ALA, O 2.86Å
A, 535, GLY, HA1 B, 532, VAL, O 2.82Å
A, 536, VAL, HA B, 535, GLY, O 3.42Å