Integral membrane protein 2C

UniProt data

UniProt name: ITM2C_HUMAN (Q9NQX7)

Gene name: ITM2C; Synonyms=BRI3; ORFNames=hucep-14, NPD018, PSEC0047

Organism: Homo sapiens (Human).

Function: Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C- terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity). {ECO:0000250, ECO:0000269|PubMed:18452648, ECO:0000269|PubMed:19366692}.

Subcellular location: Lysosome membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:19114711}; Single-pass type II membrane protein {ECO:0000269|PubMed:19114711}.

Transmembrane domains:

  1. 55-75, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 267 AA

10 20 30 40 50 60 MVKISFQPAV AGIKGDKADK ASASAPAPAS ATEILLTPAR EEQPPQHRSK RGGSVGGVCY 70 80 90 100 110 120 LSMGMVVLLM GLVFASVYIY RYFFLAQLAR DNFFRCGVLY EDSLSSQVRT QMELEEDVKI 130 140 150 160 170 180 YLDENYERIN VPVPQFGGGD PADIIHDFQR GLTAYHDISL DKCYVIELNT TIVLPPRNFW 190 200 210 220 230 240 ELLMNVKRGT YLPQTYIIQE EMVVTEHVSD KEALGSFIYH LCNGKDTYRL RRRATRRRIN 250 260 KRGAKNCNAI RHFENTFVVE TLICGVV

CATM prediction

The sequence of ITM2C_HUMAN returned 4 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          60        70       
   +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 GGSVGGVCYLSMGMVVLLMGLVFASVY 7.4 -43.0° 2.4 44.0 -24.2
Model 2 GGSVGGVCYLSMGMVVLLMGLVFASVY 7.1 -42.0° 1.9 33.0 -7.4
Model 3 GGSVGGVCYLSMGMVVLLMGLVFASVY 6.6 -47.0° 6.0 45.0 -1.5
Model 4 GGSVGGVCYLSMGMVVLLMGLVFASVY 7.2 -55.2° 2.4 47.8 -0.4

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 68, LEU, HA A, 67, VAL, O 3.44Å
B, 71, GLY, HA1 A, 68, LEU, O 3.36Å
A, 60, TYR, HH B, 60, TYR, OH 2.11Å
A, 68, LEU, HA B, 67, VAL, O 3.44Å
A, 71, GLY, HA1 B, 68, LEU, O 3.36Å