Neural proliferation differentiation and control protein 1

UniProt data

UniProt name: NPDC1_HUMAN (Q9NQX5)

Gene name: NPDC1

Organism: Homo sapiens (Human).

Function: Suppresses oncogenic transformation in neural and non- neural cells and down-regulates neural cell proliferation. Might be involved in transcriptional regulation (By similarity). {ECO:0000250}.

Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 182-202, 21 AA, Helical. {ECO:0000255}.

Sequence: 325 AA

10 20 30 40 50 60 MATPLPPPSP RHLRLLRLLL SGLVLGAALR GAAAGHPDVA ACPGSLDCAL KRRARCPPGA 70 80 90 100 110 120 HACGPCLQPF QEDQQGLCVP RMRRPPGGGR PQPRLEDEID FLAQELARKE SGHSTPPLPK 130 140 150 160 170 180 DRQRLPEPAT LGFSARGQGL ELGLPSTPGT PTPTPHTSLG SPVSSDPVHM SPLEPRGGQG 190 200 210 220 230 240 DGLALVLILA FCVAGAAALS VASLCWCRLQ REIRLTQKAD YATAKAPGSP AAPRISPGDQ 250 260 270 280 290 300 RLAQSAEMYH YQHQRQQMLC LERHKEPPKE LDTASSDEEN EDGDFTVYEC PGLAPTGEME 310 320 VRNPLFDHAA LSAPLPAPSS PPALP

CATM prediction

The sequence of NPDC1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
   180       190       200   
 |    +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 QGDGLALVLILAFCVAGAAALSVASLC 7.0 -54.1° 2.5 33.6 -4.0

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 192, CYS, HA A, 191, PHE, O 3.33Å
B, 195, GLY, HA1 A, 192, CYS, O 3.00Å
A, 192, CYS, HA B, 191, PHE, O 3.33Å
A, 195, GLY, HA1 B, 192, CYS, O 3.00Å