Nectin-3

UniProt data

UniProt name: NECT3_HUMAN (Q9NQS3)

Gene name: NECTIN3 {ECO:0000312|HGNC:HGNC:17664}; Synonyms=PRR3, PVRL3

Organism: Homo sapiens (Human).

Function: Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis- mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body. {ECO:0000269|PubMed:16216929}.

Subcellular location: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}.

Transmembrane domains:

  1. 405-425, 21 AA, Helical. {ECO:0000255}.

Sequence: 549 AA

10 20 30 40 50 60 MARTLRPSPL CPGGGKAQLS SASLLGAGLL LQPPTPPPLL LLLFPLLLFS RLCGALAGPI 70 80 90 100 110 120 IVEPHVTAVW GKNVSLKCLI EVNETITQIS WEKIHGKSSQ TVAVHHPQYG FSVQGEYQGR 130 140 150 160 170 180 VLFKNYSLND ATITLHNIGF SDSGKYICKA VTFPLGNAQS STTVTVLVEP TVSLIKGPDS 190 200 210 220 230 240 LIDGGNETVA AICIAATGKP VAHIDWEGDL GEMESTTTSF PNETATIISQ YKLFPTRFAR 250 260 270 280 290 300 GRRITCVVKH PALEKDIRYS FILDIQYAPE VSVTGYDGNW FVGRKGVNLK CNADANPPPF 310 320 330 340 350 360 KSVWSRLDGQ WPDGLLASDN TLHFVHPLTF NYSGVYICKV TNSLGQRSDQ KVIYISDPPT 370 380 390 400 410 420 TTTLQPTIQW HPSTADIEDL ATEPKKLPFP LSTLATIKDD TIATIIASVV GGALFIVLVS 430 440 450 460 470 480 VLAGIFCYRR RRTFRGDYFA KNYIPPSDMQ KESQIDVLQQ DELDSYPDSV KKENKNPVNN 490 500 510 520 530 540 LIRKDYLEEP EKTQWNNVEN LNRFERPMDY YEDLKMGMKF VSDEHYDENE DDLVSHVDGS VISRREWYV

CATM prediction

The sequence of NECT3_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          410       420      
   +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 IATIIASVVGGALFIVLVSVLAGIFCY 6.9 -49.0° 2.8 32.4 -31.9
Model 2 IATIIASVVGGALFIVLVSVLAGIFCY 7.3 -50.8° 3.3 48.1 -18.6

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 408, SER, HA A, 407, ALA, O 3.28Å
B, 411, GLY, HA1 A, 408, SER, O 3.00Å
A, 408, SER, HA B, 407, ALA, O 3.28Å
A, 411, GLY, HA1 B, 408, SER, O 3.00Å