Equatorin

UniProt data

UniProt name: EQTN_HUMAN (Q9NQ60)

Gene name: EQTN; Synonyms=AFAF, C9orf11

Organism: Homo sapiens (Human).

Function: Acrosomal membrane-anchored protein involved in the process of fertilization and in acrosome biogenesis. {ECO:0000250}.

Subcellular location: Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, acrosome outer membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=In the anterior acrosome region, enriched on the inner acrosomal membrane but minimal on the outer acrosomal membrane; in contrast in the posterior acrosome region enriched on both the inner and outer acrosomal membranes. {ECO:0000250}.

Transmembrane domains:

  1. 182-202, 21 AA, Helical. {ECO:0000255}.

Sequence: 294 AA

10 20 30 40 50 60 MNFILFIFIP GVFSLKSSTL KPTIEALPNV LPLNEDVNKQ EEKNEDHTPN YAPANEKNGN 70 80 90 100 110 120 YYKDIKQYVF TTQNPNGTES EISVRATTDL NFALKNDKTV NATTYEKSTI EEETTTSEPS 130 140 150 160 170 180 HKNIQRSTPN VPAFWTMLAK AINGTAVVMD DKDQLFHPIP ESDVNATQGE NQPDLEDLKI 190 200 210 220 230 240 KIMLGISLMT LLLFVVLLAF CSATLYKLRH LSYKSCESQY SVNPELATMS YFHPSEGVSD 250 260 270 280 290 TSFSKSAESS TFLGTTSSDM RRSGTRTSES KIMTDIISIG SDNEMHENDE SVTR

CATM prediction

The sequence of EQTN_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
   180       190       200   
 |    +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 KIKIMLGISLMTLLLFVVLLAFCSATL 7.1 -50.0° 2.9 47.0 -11.1

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 185, GLY, HA1 A, 182, ILE, O 3.07Å
A, 185, GLY, HA1 B, 182, ILE, O 3.07Å