Complement component C1q receptor

UniProt data

UniProt name: C1QR1_HUMAN (Q9NPY3)

Gene name: CD93; Synonyms=C1QR1, MXRA4

Organism: Homo sapiens (Human).

Function: Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 581-601, 21 AA, Helical. {ECO:0000255}.

Sequence: 652 AA

10 20 30 40 50 60 MATSMGLLLL LLLLLTQPGA GTGADTEAVV CVGTACYTAH SGKLSAAEAQ NHCNQNGGNL 70 80 90 100 110 120 ATVKSKEEAQ HVQRVLAQLL RREAALTARM SKFWIGLQRE KGKCLDPSLP LKGFSWVGGG 130 140 150 160 170 180 EDTPYSNWHK ELRNSCISKR CVSLLLDLSQ PLLPSRLPKW SEGPCGSPGS PGSNIEGFVC 190 200 210 220 230 240 KFSFKGMCRP LALGGPGQVT YTTPFQTTSS SLEAVPFASA ANVACGEGDK DETQSHYFLC 250 260 270 280 290 300 KEKAPDVFDW GSSGPLCVSP KYGCNFNNGG CHQDCFEGGD GSFLCGCRPG FRLLDDLVTC 310 320 330 340 350 360 ASRNPCSSSP CRGGATCVLG PHGKNYTCRC PQGYQLDSSQ LDCVDVDECQ DSPCAQECVN 370 380 390 400 410 420 TPGGFRCECW VGYEPGGPGE GACQDVDECA LGRSPCAQGC TNTDGSFHCS CEEGYVLAGE 430 440 450 460 470 480 DGTQCQDVDE CVGPGGPLCD SLCFNTQGSF HCGCLPGWVL APNGVSCTMG PVSLGPPSGP 490 500 510 520 530 540 PDEEDKGEKE GSTVPRAATA SPTRGPEGTP KATPTTSRPS LSSDAPITSA PLKMLAPSGS 550 560 570 580 590 600 PGVWREPSIH HATAASGPQE PAGGDSSVAT QNNDGTDGQK LLLFYILGTV VAILLLLALA 610 620 630 640 650 LGLLVYRKRR AKREEKKEKK PQNAADSYSW VPERAESRAM ENQYSPTPGT DC

CATM prediction

The sequence of C1QR1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    580       590       600  
  |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 GQKLLLFYILGTVVAILLLLALALGLL 7.2 -54.7° 0.9 49.8 -16.8

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 588, GLY, HA1 A, 585, TYR, O 3.16Å
B, 589, THR, HA A, 588, GLY, O 3.45Å
A, 588, GLY, HA1 B, 585, TYR, O 3.16Å
A, 589, THR, HA B, 588, GLY, O 3.45Å